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dc.contributor.authorSinha, Sanjay
dc.contributor.authorSantoro, Massimo Mattia
dc.date.accessioned2018-03-20T15:54:59Z
dc.date.available2018-03-20T15:54:59Z
dc.date.issued2018-03-15
dc.identifier.issn0008-6363
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274139
dc.description.abstractA key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells (SMCs) and pericytes influences vessel properties, in particular the regional propensity to vascular diseases. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryonic origin. We then consider the evidence that connects heterogeneities in SMC and pericyte origins with disease. Since this idea has major implications for understanding and modelling human disease, then there is a pressing need for new model systems to investigate mural cell development and the consequences of heterogeneity. Recent advances arising from in vitro strategies for deriving mural cells from human pluripotent stem cells as well as from the zebrafish model will be discussed and the medical relevance of these discoveries will be highlighted.
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMyocytes, Smooth Muscle
dc.subjectAnimals
dc.subjectZebrafish
dc.subjectHumans
dc.subjectVascular Diseases
dc.subjectCell Communication
dc.subjectSignal Transduction
dc.subjectGene Expression Regulation, Developmental
dc.subjectCell Lineage
dc.subjectNeovascularization, Physiologic
dc.subjectPhenotype
dc.subjectEmbryonic Stem Cells
dc.subjectInduced Pluripotent Stem Cells
dc.titleNew models to study vascular mural cell embryonic origin: implications in vascular diseases.
dc.typeArticle
prism.endingPage491
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameCardiovasc Res
prism.startingPage481
prism.volume114
dc.identifier.doi10.17863/CAM.21224
dcterms.dateAccepted2018-01-23
rioxxterms.versionofrecord10.1093/cvr/cvy005
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-03
dc.contributor.orcidSinha, Sanjay [0000-0001-5900-1209]
dc.identifier.eissn1755-3245
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (MC_PC_12009)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (FS/18/46/33663)
pubs.funder-project-idBritish Heart Foundation (RG/17/5/32936)
cam.issuedOnline2018-01-27
rioxxterms.freetoread.startdate2019-01-27


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International