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dc.contributor.authorSinha, Sanjayen
dc.contributor.authorSantoro, Massimo Mattiaen
dc.date.accessioned2018-03-20T15:54:59Z
dc.date.available2018-03-20T15:54:59Z
dc.date.issued2018-03en
dc.identifier.issn0008-6363
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274139
dc.description.abstractA key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells and pericytes influences vessel properties, in particular the regional propensity to vascular diseases. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryonic origin. We then consider the evidence that connects heterogeneities in smooth muscle cell and pericyte origins with disease. Since this idea has major implications for understanding and modelling human disease, then there is a pressing need for new model systems to investigate mural cell development and the consequences of heterogeneity. Recent advances arising from in vitro strategies for deriving mural cells from human pluripotent stem cells as well as from the zebrafish model will be discussed and the medical relevance of these discoveries will be highlighted.
dc.format.mediumPrinten
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMyocytes, Smooth Muscleen
dc.subjectAnimalsen
dc.subjectZebrafishen
dc.subjectHumansen
dc.subjectVascular Diseasesen
dc.subjectCell Communicationen
dc.subjectSignal Transductionen
dc.subjectGene Expression Regulation, Developmentalen
dc.subjectCell Lineageen
dc.subjectNeovascularization, Physiologicen
dc.subjectPhenotypeen
dc.subjectEmbryonic Stem Cellsen
dc.subjectInduced Pluripotent Stem Cellsen
dc.titleNew models to study vascular mural cell embryonic origin: implications in vascular diseases.en
dc.typeArticle
prism.endingPage491
prism.issueIdentifier4en
prism.publicationDate2018en
prism.publicationNameCardiovascular researchen
prism.startingPage481
prism.volume114en
dc.identifier.doi10.17863/CAM.21224
dcterms.dateAccepted2018-01-23en
rioxxterms.versionofrecord10.1093/cvr/cvy005en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-03en
dc.contributor.orcidSinha, Sanjay [0000-0001-5900-1209]
dc.contributor.orcidSantoro, Massimo Mattia [0000-0003-4605-5085]
dc.identifier.eissn1755-3245
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (FS/13/29/30024)
pubs.funder-project-idMRC (MC_PC_12009)
pubs.funder-project-idBritish Heart Foundation (FS/13/65/30441)
rioxxterms.freetoread.startdate2019-01-27


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International