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dc.contributor.authorVan Grootel, Tom J
dc.contributor.authorMeeson, Alan
dc.contributor.authorMunk, Matthias HJ
dc.contributor.authorKourtzi, Zoe
dc.contributor.authorMovshon, J Anthony
dc.contributor.authorLogothetis, Nikos K
dc.contributor.authorKiorpes, Lynne
dc.date.accessioned2018-03-21T12:00:15Z
dc.date.available2018-03-21T12:00:15Z
dc.date.issued2017
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274154
dc.description.abstractFunctional brain development is not well understood. In the visual system, neurophysiological studies in nonhuman primates show quite mature neuronal properties near birth although visual function is itself quite immature and continues to develop over many months or years after birth. Our goal was to assess the relative development of two main visual processing streams, dorsal and ventral, using BOLD fMRI in an attempt to understand the global mechanisms that support the maturation of visual behavior. Seven infant macaque monkeys (Macaca mulatta) were repeatedly scanned, while anesthetized, over an age range of 102 to 1431 days. Large rotating checkerboard stimuli induced BOLD activation in visual cortices at early ages. Additionally we used static and dynamic Glass pattern stimuli to probe BOLD responses in primary visual cortex and two extrastriate areas: V4 and MT-V5. The resulting activations were analyzed with standard GLM and multivoxel pattern analysis (MVPA) approaches. We analyzed three contrasts: Glass pattern present/absent, static/dynamic Glass pattern presentation, and structured/random Glass pattern form. For both GLM and MVPA approaches, robust coherent BOLD activation appeared relatively late in comparison to the maturation of known neuronal properties and the development of behavioral sensitivity to Glass patterns. Robust differential activity to Glass pattern present/absent and dynamic/static stimulus presentation appeared first in V1, followed by V4 and MT-V5 at older ages; there was no reliable distinction between the two extrastriate areas. A similar pattern of results was obtained with the two analysis methods, although MVPA analysis showed reliable differential responses emerging at later ages than GLM. Although BOLD responses to large visual stimuli are detectable, our results with more refined stimuli indicate that global BOLD activity changes as behavioral performance matures. This reflects an hierarchical development of the visual pathways. Since fMRI BOLD reflects neural activity on a population level, our results indicate that, although individual neurons might be adult-like, a longer maturation process takes place on a population level.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectVisual Cortex
dc.subjectAnimals
dc.subjectMacaca mulatta
dc.subjectMagnetic Resonance Imaging
dc.subjectLinear Models
dc.subjectFemale
dc.subjectMale
dc.titleDevelopment of visual cortical function in infant macaques: A BOLD fMRI study.
dc.typeArticle
prism.issueIdentifier11
prism.publicationDate2017
prism.publicationNamePLoS One
prism.startingPagee0187942
prism.volume12
dc.identifier.doi10.17863/CAM.21237
dcterms.dateAccepted2017-10-28
rioxxterms.versionofrecord10.1371/journal.pone.0187942
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-01
dc.contributor.orcidVan Grootel, Tom J [0000-0001-6372-4573]
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission (290011)
cam.issuedOnline2017-11-16


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International