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dc.contributor.authorBüchel, Christian
dc.contributor.authorPeters, Jan
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBokde, Arun LW
dc.contributor.authorBromberg, Uli
dc.contributor.authorConrod, Patricia J
dc.contributor.authorFlor, Herta
dc.contributor.authorPapadopoulos, Dimitri
dc.contributor.authorGaravan, Hugh
dc.contributor.authorGowland, Penny
dc.contributor.authorHeinz, Andreas
dc.contributor.authorWalter, Henrik
dc.contributor.authorIttermann, Bernd
dc.contributor.authorMann, Karl
dc.contributor.authorMartinot, Jean-Luc
dc.contributor.authorPaillère-Martinot, Marie-Laure
dc.contributor.authorNees, Frauke
dc.contributor.authorPaus, Tomas
dc.contributor.authorPausova, Zdenka
dc.contributor.authorPoustka, Luise
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRobbins, Trevor W
dc.contributor.authorSmolka, Michael N
dc.contributor.authorGallinat, Juergen
dc.contributor.authorSchumann, Gunter
dc.contributor.authorKnutson, Brian
dc.contributor.authorIMAGEN consortium
dc.date.accessioned2018-03-26T13:12:25Z
dc.date.available2018-03-26T13:12:25Z
dc.date.issued2017-02-21
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274342
dc.description.abstractNovelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectIMAGEN consortium
dc.subjectMesencephalon
dc.subjectPrefrontal Cortex
dc.subjectHumans
dc.subjectSubstance-Related Disorders
dc.subjectMagnetic Resonance Imaging
dc.subjectBrain Mapping
dc.subjectLongitudinal Studies
dc.subjectExploratory Behavior
dc.subjectImpulsive Behavior
dc.subjectMotivation
dc.subjectReward
dc.subjectAdolescent
dc.subjectFemale
dc.subjectMale
dc.subjectAnticipation, Psychological
dc.subjectVentral Striatum
dc.titleBlunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents.
dc.typeArticle
prism.publicationDate2017
prism.publicationNameNat Commun
prism.startingPage14140
prism.volume8
dc.identifier.doi10.17863/CAM.21464
dcterms.dateAccepted2016-12-02
rioxxterms.versionofrecord10.1038/ncomms14140
rioxxterms.versionNA
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-02-21
dc.contributor.orcidPapadopoulos, Dimitri [0000-0002-1242-8990]
dc.contributor.orcidSmolka, Michael N [0000-0001-5398-5569]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-02-21


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International