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dc.contributor.authorSavulich, George
dc.contributor.authorMezquida, Gisela
dc.contributor.authorAtkinson, Samuel
dc.contributor.authorBernardo, Miguel
dc.contributor.authorFernandez-Egea, Emilio
dc.date.accessioned2018-03-27T14:39:07Z
dc.date.available2018-03-27T14:39:07Z
dc.date.issued2018-04
dc.identifier.issn0271-0749
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274428
dc.description.abstractCognitive dysfunction is a hallmark feature of schizophrenia, often presenting in patients with psychotic disorders since the first episode (1) or earlier (2). Antipsychotic medication is effective for treating the positive symptoms of psychosis, but their potential for therapeutic effects on cognition continues to divide researchers (3). Acute psychotic symptoms impair several cognitive domains, and medication (or lack of) in turn impacts the degree of psychosis. Improvements in clinical symptoms can occur independently of cognitive functioning, whereby typical antipsychotics improve different clinical domains, but have little or no efficacy for improving primary cognitive functions. However, it has been suggested that the second-generation antipsychotic clozapine can improve cognition in schizophrenia (4, 5). Unusual cases, such as remitted patients who decide to stop taking clozapine, thus represent a unique opportunity to understand the effect of antipsychotic medication on cognition, as described in the case study below.
dc.format.mediumPrint
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectHumans
dc.subjectClozapine
dc.subjectAntipsychotic Agents
dc.subjectSchizophrenia
dc.subjectAdult
dc.subjectMale
dc.subjectCognitive Dysfunction
dc.titleA Case Study of Clozapine and Cognition: Friend or Foe?
dc.typeArticle
prism.endingPage153
prism.issueIdentifier2
prism.publicationDate2018
prism.publicationNameJ Clin Psychopharmacol
prism.startingPage152
prism.volume38
dc.identifier.doi10.17863/CAM.21553
dcterms.dateAccepted2017-12-11
rioxxterms.versionofrecord10.1097/JCP.0000000000000847
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-04
dc.contributor.orcidSavulich, George [0000-0002-6513-5454]
dc.contributor.orcidBernardo, Miguel [0000-0001-8748-6717]
dc.identifier.eissn1533-712X
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2019-03-27


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