Geometrical Effect in 2D Nanopores
Alexander, Duncan TL
American Chemical Society
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Liu, K., Lihter, M., Sarathy, A., Caneva, S., Qiu, H., Deiana, D., Tileli, V., et al. (2017). Geometrical Effect in 2D Nanopores. Nano Letters, 17 (7), 4223-4230. https://doi.org/10.1021/acs.nanolett.7b01091
A long-standing problem in the application of solid-state nanopores is the lack of the precise control over the geometry of artificially formed pores compared to the well-defined geometry in their biological counterpart, that is, protein nanopores. To date, experimentally investigated solid-state nanopores have been shown to adopt an approximately circular shape. In this Letter, we investigate the geometrical effect of the nanopore shape on ionic blockage induced by DNA translocation using triangular h-BN nanopores and approximately circular molybdenum disulfide (MoS2) nanopores. We observe a striking geometry-dependent ion scattering effect, which is further corroborated by a modified ionic blockage model. The well-acknowledged ionic blockage model is derived from uniform ion permeability through the 2D nanopore plane and hemisphere like access region in the nanopore vicinity. On the basis of our experimental results, we propose a modified ionic blockage model, which is highly related to the ionic profile caused by geometrical variations. Our findings shed light on the rational design of 2D nanopores and should be applicable to arbitrary nanopore shapes.
2D materials, Solid-state nanopores, hexagonal boron nitride (h-BN), high-resolution transmission electron microscopy (HRTEM), ion transport, molybdenum disulfide (MoS2)
This work was financially supported by the European Research Council (grant 259398, PorABEL), by a Swiss National Science Foundation (SNSF) Consolidator grant (BIONIC BSCGI0_157802), by SNSF Sinergia grant 147607 ... The work performed in Cambridge was supported by the EPSRC Cambridge NanoDTC, EP/L015978/1. The work performed in UIUC was supported by grants from Oxford Nanopore Technology and the Seeding Novel Interdisciplinary Research Program of the Beckman Institute. The UIUC authors gratefully acknowledge also supercomputer time provided through the Extreme Science and Engineering Discovery Environment (XSEDE) grant MCA93S028 and by the University of Illinois at Urbana-Champaign on the TAUB cluster.
External DOI: https://doi.org/10.1021/acs.nanolett.7b01091
This record's URL: https://www.repository.cam.ac.uk/handle/1810/274479