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KRAS Allelic Imbalance: Strengths and Weaknesses in Numbers.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Doherty, Gary J 
Kerr, Emma M 
Martins, Carla P 

Abstract

The identification of therapeutic vulnerabilities in mutant KRAS tumors has proven difficult to achieve. Burgess and colleagues recently reported in Cell that mutant/wild-type Kras allelic dosage determines clonal fitness and MEK inhibitor sensitivity in a leukemia model, demonstrating that KRAS allelic imbalance is likely an important and overlooked variable.

Description

Keywords

Allelic Imbalance, Benzamides, Diphenylamine, Gene Dosage, Humans, Leukemia, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Models, Theoretical, Proto-Oncogene Proteins p21(ras)

Journal Title

Trends Mol Med

Conference Name

Journal ISSN

1471-4914
1471-499X

Volume Title

23

Publisher

Elsevier BV
Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_12022/4)