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dc.contributor.authorIyadurai, Len
dc.contributor.authorBlackwell, SEen
dc.contributor.authorMeiser-Stedman, Richarden
dc.contributor.authorWatson, Peteren
dc.contributor.authorBonsall, MBen
dc.contributor.authorGeddes, JRen
dc.contributor.authorNobre, ACen
dc.contributor.authorHolmes, Emilyen
dc.date.accessioned2018-03-29T13:36:05Z
dc.date.available2018-03-29T13:36:05Z
dc.date.issued2018-03en
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274508
dc.description.abstractAfter psychological trauma, recurrent intrusive visual memories may be distressing and disruptive. Preventive interventions post trauma are lacking. Here we test a behavioural intervention after real-life trauma derived from cognitive neuroscience. We hypothesized that intrusive memories would be significantly reduced in number by an intervention involving a computer game with high visuospatial demands (Tetris), via disrupting consolidation of sensory elements of trauma memory. The Tetris-based intervention (trauma memory reminder cue plus c. 20 min game play) vs attention-placebo control (written activity log for same duration) were both delivered in an emergency department within 6 h of a motor vehicle accident. The randomized controlled trial compared the impact on the number of intrusive trauma memories in the subsequent week (primary outcome). Results vindicated the efficacy of the Tetris-based intervention compared with the control condition: there were fewer intrusive memories overall, and time-series analyses showed that intrusion incidence declined more quickly. There were convergent findings on a measure of clinical post-trauma intrusion symptoms at 1 week, but not on other symptom clusters or at 1 month. Results of this proof-of-concept study suggest that a larger trial, powered to detect differences at 1 month, is warranted. Participants found the intervention easy, helpful and minimally distressing. By translating emerging neuroscientific insights and experimental research into the real world, we offer a promising new low-intensity psychiatric intervention that could prevent debilitating intrusive memories following trauma.Molecular Psychiatry advance online publication, 28 March 2017; doi:10.1038/mp.2017.23.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHumansen
dc.subjectWounds and Injuriesen
dc.subjectSyndromeen
dc.subjectCognitionen
dc.subjectMemoryen
dc.subjectStress Disorders, Post-Traumaticen
dc.subjectBehavior Therapyen
dc.subjectVideo Gamesen
dc.subjectAdulten
dc.subjectMiddle Ageden
dc.subjectEmergency Service, Hospitalen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectPsychological Traumaen
dc.subjectProof of Concept Studyen
dc.titlePreventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial.en
dc.typeArticle
prism.endingPage682
prism.issueIdentifier3en
prism.publicationDate2018en
prism.publicationNameMolecular psychiatryen
prism.startingPage674
prism.volume23en
dc.identifier.doi10.17863/CAM.21628
dcterms.dateAccepted2017-01-17en
rioxxterms.versionofrecord10.1038/mp.2017.23en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-03en
dc.contributor.orcidBlackwell, SE [0000-0002-3313-7084]
dc.contributor.orcidMeiser-Stedman, Richard [0000-0002-0262-623X]
dc.contributor.orcidWatson, Peter [0000-0002-9436-0693]
dc.contributor.orcidNobre, AC [0000-0001-5762-2802]
dc.contributor.orcidHolmes, Emily [0000-0001-7319-3112]
dc.identifier.eissn1476-5578
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMedical Research Council (MC_UU_00005/14)
cam.orpheus.successThu Jan 30 12:58:19 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International