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dc.contributor.authorZou, Gengen
dc.contributor.authorZhou, Jianweien
dc.contributor.authorXiao, Ranen
dc.contributor.authorZhang, Liangshengen
dc.contributor.authorCheng, Yutingen
dc.contributor.authorJin, Huien
dc.contributor.authorLi, Luen
dc.contributor.authorZhang, Lijunen
dc.contributor.authorWu, Binen
dc.contributor.authorQian, Pingen
dc.contributor.authorLi, Shaowenen
dc.contributor.authorRen, Lixinen
dc.contributor.authorWang, Jinhongen
dc.contributor.authorOshota, Olusegunen
dc.contributor.authorHernandez-Garcia, Juanen
dc.contributor.authorWileman, Thomasen
dc.contributor.authorBentley, Stephenen
dc.contributor.authorWeinert, Lucyen
dc.contributor.authorMaskell, Duncanen
dc.contributor.authorTucker, Alexanderen
dc.contributor.authorZhou, Ruien
dc.date.accessioned2018-03-29T15:42:38Z
dc.date.available2018-03-29T15:42:38Z
dc.date.issued2018-04-02en
dc.identifier.issn0099-2240
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274527
dc.description.abstractStreptococcus suis (S. suis), a global zoonosis of pigs, shows regional differences in prevalence of human associated disease for Asian and non-Asian countries. The isolation rate and diversity of S. suis on tonsils of healthy slaughter pigs in China and the UK were studied for effects of geography, temperature, pig age and farm type. Isolates underwent analysis of molecular serotype, multilocus sequence type, and virulence-associated genotyping. Although we found no significant difference in positive isolation rates between Chinese and UK farms, the prevalences of serotypes previously associated with human disease were significantly greater in the Chinese collection (p = 0.003). A significant effect of temperature was found on the positive isolation rate of the Chinese samples and prevalence of human disease associated serotypes in the UK S. suis population (China, p = 0.004; UK, p = 0.024), and on the prevalence of isolates carrying key virulence genes in China (p = 0.044). Finally, we found marked diversity among S. suis isolates with statistically significant temperature effects on detection of multiple strain types within individual pigs. This study highlighted the high carriage prevalence and diversity of S. suis among clinically healthy pig herds of China and the UK. The significant effect of temperature on prevalence of isolation, human disease associated serotypes and diversity carried by individual pigs may shed new light on geographic variations in human S. suis associated disease.
dc.format.mediumElectronic-Printen
dc.languageengen
dc.subjectAnimalsen
dc.subjectSwineen
dc.subjectStreptococcus suisen
dc.subjectStreptococcal Infectionsen
dc.subjectSwine Diseasesen
dc.subjectPrevalenceen
dc.subjectLongitudinal Studiesen
dc.subjectTemperatureen
dc.subjectAge Factorsen
dc.subjectGenome, Bacterialen
dc.subjectAnimal Husbandryen
dc.subjectChinaen
dc.subjectGenetic Variationen
dc.subjectUnited Kingdomen
dc.titleEffects of Environmental and Management-Associated Factors on Prevalence and Diversity of Streptococcus suis in Clinically Healthy Pig Herds in China and the United Kingdom.en
dc.typeArticle
prism.issueIdentifier8en
prism.publicationDate2018en
prism.publicationNameApplied and environmental microbiologyen
prism.volume84en
dc.identifier.doi10.17863/CAM.21648
dcterms.dateAccepted2018-01-23en
rioxxterms.versionofrecord10.1128/aem.02590-17en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-04-02en
dc.contributor.orcidHernandez-Garcia, Juan [0000-0001-5932-9327]
dc.contributor.orcidWeinert, Lucy [0000-0002-9279-6012]
dc.contributor.orcidMaskell, Duncan [0000-0002-5065-653X]
dc.contributor.orcidTucker, Alexander [0000-0003-0062-0843]
dc.identifier.eissn1098-5336
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/J020664/1)
pubs.funder-project-idBBSRC (BB/L003902/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (727966)
pubs.funder-project-idBBSRC (BB/G019274/1)
pubs.funder-project-idRoyal Society (DH140195)
pubs.funder-project-idWELLCOME TRUST (109385/Z/15/Z)
rioxxterms.freetoread.startdate2018-08-02


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