Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications.
Ivyspring International Publisher
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Wu, W., Luo, L., Wang, Y., Wu, Q., Dai, H., Li, J., Durkan, C., et al. (2018). Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications.. Theranostics, 8 (11), 3038-3058. https://doi.org/10.7150/thno.23459
Antitumor drug delivery systems ("Nanocarriers") based on nanotechnology have started to demonstrate their efficacy in recent years. The optimum size of these nanocarriers is paramount and must be designed uniquely for each type of delivery process, but is typically around 100 nm. Different pH (~ 6.5 for tumor tissue, ~ 5.5 for endosome, and ~ 5.0 for lysosome) may serve as an endogenous stimulus when it comes to designing pH-responsive nanocarriers with programmable size change to satisfy the diverse size requirements for ultimately improving the therapeutic efficacy and safety of antitumor drugs. This review focuses on current advanced pH-responsive nanocarriers with programmable size change for anticancer drug delivery. In particular, pH-responsive mechanisms for nanocarrier retention at tumor sites, size reduction for penetrating into tumor parenchyma escaping from endo/lysosome escape, and swelling or disassembly for drug release will be highlighted. Additional trends and challenges of pH-responsive nanocarriers with programmable size change in future clinical applications are also addressed.
Endosomes, Lysosomes, Neoplasms, Antineoplastic Agents, Drug Carriers, Drug Delivery Systems, Hydrogen-Ion Concentration, Particle Size, Nanotechnology, Nanoparticles, Drug Liberation
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External DOI: https://doi.org/10.7150/thno.23459
This record's URL: https://www.repository.cam.ac.uk/handle/1810/274600
Attribution-NonCommercial 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc/4.0/