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dc.contributor.authorWu, Weien
dc.contributor.authorLuo, Lien
dc.contributor.authorWang, Yien
dc.contributor.authorWu, Qien
dc.contributor.authorDai, Han-Binen
dc.contributor.authorLi, Jian-Shuen
dc.contributor.authorDurkan, Colmen
dc.contributor.authorWang, Nanen
dc.contributor.authorWang, Gui-Xueen
dc.date.accessioned2018-04-05T15:47:41Z
dc.date.available2018-04-05T15:47:41Z
dc.date.issued2018-01en
dc.identifier.issn1838-7640
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274600
dc.description.abstractAntitumor drug delivery systems ("Nanocarriers") based on nanotechnology have started to demonstrate their efficacy in recent years. The optimum size of these nanocarriers is paramount and must be designed uniquely for each type of delivery process, but is typically around 100 nm. Different pH (~ 6.5 for tumor tissue, ~ 5.5 for endosome, and ~ 5.0 for lysosome) may serve as an endogenous stimulus when it comes to designing pH-responsive nanocarriers with programmable size change to satisfy the diverse size requirements for ultimately improving the therapeutic efficacy and safety of antitumor drugs. This review focuses on current advanced pH-responsive nanocarriers with programmable size change for anticancer drug delivery. In particular, pH-responsive mechanisms for nanocarrier retention at tumor sites, size reduction for penetrating into tumor parenchyma escaping from endo/lysosome escape, and swelling or disassembly for drug release will be highlighted. Additional trends and challenges of pH-responsive nanocarriers with programmable size change in future clinical applications are also addressed.
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.publisherIvyspring International Publisher
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectEndosomesen
dc.subjectLysosomesen
dc.subjectNeoplasmsen
dc.subjectAntineoplastic Agentsen
dc.subjectDrug Carriersen
dc.subjectDrug Delivery Systemsen
dc.subjectHydrogen-Ion Concentrationen
dc.subjectParticle Sizeen
dc.subjectNanotechnologyen
dc.subjectNanoparticlesen
dc.subjectDrug Liberationen
dc.titleEndogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications.en
dc.typeArticle
prism.endingPage3058
prism.issueIdentifier11en
prism.publicationDate2018en
prism.publicationNameTheranosticsen
prism.startingPage3038
prism.volume8en
dc.identifier.doi10.17863/CAM.21740
dcterms.dateAccepted2018-03-06en
rioxxterms.versionofrecord10.7150/thno.23459en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-01en
dc.contributor.orcidDurkan, Colm [0000-0001-9398-2813]
dc.contributor.orcidWang, Nan [0000-0002-7370-5998]
dc.identifier.eissn1838-7640
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:59:55 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International