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dc.contributor.authorShearer, Jamesen
dc.contributor.authorPapanikolaou, Nestoren
dc.contributor.authorMeiser-Stedman, Richarden
dc.contributor.authorMcKinnon, Annaen
dc.contributor.authorDalgleish, Timen
dc.contributor.authorSmith, Patricken
dc.contributor.authorDixon, Clareen
dc.contributor.authorByford, Sarahen
dc.date.accessioned2018-04-13T09:59:40Z
dc.date.available2018-04-13T09:59:40Z
dc.date.issued2018-07en
dc.identifier.issn0021-9630
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274841
dc.description.abstractBACKGROUND: Untreated post-traumatic stress disorder (PTSD) in children and adolescents is associated with a considerable economic burden on the health system, families and society. Recent research has demonstrated the potential efficacy of cognitive therapy as an early intervention for PTSD in children and adolescents. Children who experienced a single traumatic event in the previous two to six months and were randomized to cognitive therapy for PTSD (CT-PTSD) were significantly more likely to be PTSD-free compared to those randomized to usual care represented by waitlist control. The current study evaluated the economic impact of improvements in the treatment of PTSD in children and adolescents. METHODS: A cost-effectiveness analysis was conducted from the national health service/personal social services perspective with outcomes expressed as quality-adjusted life years (QALYs). Patient level costs and outcomes were collected during the 11 week clinical trial and extrapolated to a three year time horizon using economic modelling methods. Uncertainty was estimated using probabilistic sensitivity analysis and assumptions were tested using one way sensitivity analysis. RESULTS: The incremental cost-effectiveness ratio at 3 years was £2,205 per QALY with a 60%-69% probability of CT-PTSD being cost-effective compared to usual care at the UK £20,000 to £30,000 per QALY decision threshold. CONCLUSIONS: This study provides preliminary evidence for the cost-effectiveness of cognitive therapy in this treatment population. Larger pragmatic trials with longer follow-up are indicated.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHumansen
dc.subjectModels, Econometricen
dc.subjectFollow-Up Studiesen
dc.subjectStress Disorders, Post-Traumaticen
dc.subjectQuality-Adjusted Life Yearsen
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectCost-Benefit Analysisen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectEarly Medical Interventionen
dc.subjectCognitive Behavioral Therapyen
dc.subjectOutcome Assessment, Health Careen
dc.titleCost-effectiveness of cognitive therapy as an early intervention for post-traumatic stress disorder in children and adolescents: a trial based evaluation and model.en
dc.typeArticle
prism.endingPage780
prism.issueIdentifier7en
prism.publicationDate2018en
prism.publicationNameJournal of child psychology and psychiatry, and allied disciplinesen
prism.startingPage773
prism.volume59en
dc.identifier.doi10.17863/CAM.21988
dcterms.dateAccepted2017-11-01en
rioxxterms.versionofrecord10.1111/jcpp.12851en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-07en
dc.contributor.orcidShearer, James [0000-0002-1658-9767]
dc.contributor.orcidMeiser-Stedman, Richard [0000-0002-0262-623X]
dc.contributor.orcidDalgleish, Timothy [0000-0002-7304-2231]
dc.contributor.orcidSmith, Patrick [0000-0002-0743-7972]
dc.contributor.orcidByford, Sarah [0000-0001-7084-1495]
dc.identifier.eissn1469-7610
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (unknown)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International