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dc.contributor.authorHughes, Katherineen
dc.contributor.authorWatson, Christineen
dc.date.accessioned2018-04-25T13:07:32Z
dc.date.available2018-04-25T13:07:32Z
dc.date.issued2018-06en
dc.identifier.issn1083-3021
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275158
dc.description.abstractThe ‘One Health’ concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a ‘One Health’ approach. In this review, we will evaluate the role of the mammary microenvironment in mastitis in humans, ruminants and rabbits, where appropriate also drawing on studies utilising laboratory animal models. We will examine subclinical mastitis, clinical lactational mastitis, and involution-associated, or dry period, mastitis, highlighting important anatomical and immunological species differences. We will synthesise knowledge gained across different species, comparing and contrasting disease presentation. Subclinical mastitis (SCM) is characterised by elevated Na/K ratio, and increased milk IL-8 concentrations. SCM affecting the breastfeeding mother may result in modulation of infant mucosal immune system development, whilst in ruminants notable milk production losses may ensue. In the case of clinical lactational mastitis, we will focus on mastitis caused by Staphylococcus aureus and Escherichia coli. Understanding of the pathogenesis of involution-associated mastitis requires characterization of the structural and molecular changes occurring during involution and we will review these changes across species. We speculate that milk accumulation may act as a nidus for infection, and that the involution ‘wound healing phenotype’ may render the tissue susceptible to bacterial infection. We will discuss the impact of concurrent pregnancy and a ‘parallel pregnancy and involution signature’ during bovine mammary involution.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.subjectMammary Glands, Animalen
dc.subjectAnimalsen
dc.subjectRuminantsen
dc.subjectCattleen
dc.subjectRabbitsen
dc.subjectHumansen
dc.subjectRodentiaen
dc.subjectMastitisen
dc.subjectFemaleen
dc.subjectCellular Microenvironmenten
dc.subjectOne Healthen
dc.titleThe Mammary Microenvironment in Mastitis in Humans, Dairy Ruminants, Rabbits and Rodents: A One Health Focus.en
dc.typeArticle
prism.endingPage41
prism.issueIdentifier1-2en
prism.publicationDate2018en
prism.publicationNameJournal of mammary gland biology and neoplasiaen
prism.startingPage27
prism.volume23en
dc.identifier.doi10.17863/CAM.22012
dcterms.dateAccepted2018-04-12en
rioxxterms.versionofrecord10.1007/s10911-018-9395-1en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-06en
dc.contributor.orcidHughes, Katherine [0000-0002-3331-1249]
dc.contributor.orcidWatson, Christine [0000-0002-8548-5902]
dc.identifier.eissn1573-7039
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/J001023/1)
rioxxterms.freetoread.startdate2019-04-25


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