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dc.contributor.authorCollord, Graceen
dc.contributor.authorMartincorena, Inigoen
dc.contributor.authorYoung, Matthew Den
dc.contributor.authorForoni, Letiziaen
dc.contributor.authorBolli, Niccoloen
dc.contributor.authorStratton, Michael Ren
dc.contributor.authorVassiliou, Georgeen
dc.contributor.authorCampbell, Peter Jen
dc.contributor.authorBehjati, Samen
dc.date.accessioned2018-04-30T10:54:21Z
dc.date.available2018-04-30T10:54:21Z
dc.date.issued2019-02en
dc.identifier.issn0007-1048
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275337
dc.description.abstractMutations affecting key modifiable histone type 3 (H3; Supplementary Table 1) residues are frequent oncogenic events in certain solid tumours (Feinberg, et al 2016), and have also recently been implicated in a subset of acute myeloid leukaemia (AML)(Lehnertz, et al 2017). Here, we systematically reviewed the somatic mutations in >20,000 cancer specimens to identify tumours harbouring H3 mutations. In a subset of T-cell acute lymphoblastic leukaemia (T-ALL) we identified non-methionine mutations of the key modifiable H3 residues, lysine (K) 27 and 36.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCell Line, Tumoren
dc.subjectHumansen
dc.subjectHistonesen
dc.subjectMutationen
dc.subjectPrecursor T-Cell Lymphoblastic Leukemia-Lymphomaen
dc.titleRecurrent histone mutations in T-cell acute lymphoblastic leukaemia.en
dc.typeArticle
prism.endingPage679
prism.issueIdentifier4en
prism.publicationDate2019en
prism.publicationNameBritish journal of haematologyen
prism.startingPage676
prism.volume184en
dc.identifier.doi10.17863/CAM.22527
dcterms.dateAccepted2017-12-31en
rioxxterms.versionofrecord10.1111/bjh.15155en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-02en
dc.contributor.orcidCollord, Grace [0000-0003-1924-4411]
dc.contributor.orcidBolli, Niccolo [0000-0002-1018-5139]
dc.contributor.orcidVassiliou, George [0000-0003-4337-8022]
dc.identifier.eissn1365-2141
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC 2012-2017)
pubs.funder-project-idMRC (MC_PC_12009)
cam.orpheus.successThu Jan 30 12:59:04 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International