cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway.
Basic research in cardiology
Dietrich Steinkopff Verlag
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Park, M., Sandner, P., & Krieg, T. (2018). cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway.. Basic research in cardiology, 113 (4), 24. https://doi.org/10.1007/s00395-018-0679-9
The nitric oxide (NO) – protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct size in patients have failed in the past, the advent of novel drugs that modulate cGMP and its downstream targets show very promising results in recent pre-clinical and clinical studies. Here we review main aspects of the NO – PKG pathway in light of recent drug development and summarize potential cardioprotective strategies in which cGMP is the main player.
Myocardium, Animals, Humans, Myocardial Reperfusion Injury, Nitric Oxide, Cyclic GMP-Dependent Protein Kinases, Cyclic GMP, Cardiovascular Agents, Enzyme Activators, Signal Transduction, Enzyme Activation, Heart Failure
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External DOI: https://doi.org/10.1007/s00395-018-0679-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/275344