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dc.contributor.authorPark, Minen
dc.contributor.authorSandner, Peteren
dc.contributor.authorKrieg, Thomasen
dc.date.accessioned2018-04-30T13:16:59Z
dc.date.available2018-04-30T13:16:59Z
dc.date.issued2018-05-15en
dc.identifier.issn0300-8428
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275344
dc.description.abstractThe nitric oxide (NO) – protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct size in patients have failed in the past, the advent of novel drugs that modulate cGMP and its downstream targets show very promising results in recent pre-clinical and clinical studies. Here we review main aspects of the NO – PKG pathway in light of recent drug development and summarize potential cardioprotective strategies in which cGMP is the main player.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherDietrich Steinkopff Verlag
dc.subjectMyocardiumen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectMyocardial Reperfusion Injuryen
dc.subjectNitric Oxideen
dc.subjectCyclic GMP-Dependent Protein Kinasesen
dc.subjectCyclic GMPen
dc.subjectCardiovascular Agentsen
dc.subjectEnzyme Activatorsen
dc.subjectSignal Transductionen
dc.subjectEnzyme Activationen
dc.subjectHeart Failureen
dc.titlecGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway.en
dc.typeArticle
prism.issueIdentifier4en
prism.publicationDate2018en
prism.publicationNameBasic research in cardiologyen
prism.startingPage24
prism.volume113en
dc.identifier.doi10.17863/CAM.22534
dcterms.dateAccepted2018-04-04en
rioxxterms.versionofrecord10.1007/s00395-018-0679-9en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-05-15en
dc.contributor.orcidKrieg, Thomas [0000-0002-5192-580X]
dc.identifier.eissn1435-1803
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:59:16 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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