Metaplastic Cdx2-depleted cells can be very disruptive neighbors.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Lourenço, Filipe C
Winton, Douglas J
Abstract
In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring "normal" Cdx2-positive cells.
Description
Keywords
Animals, CDX2 Transcription Factor, Carcinogenesis, Genes, Homeobox, Homeodomain Proteins, Mice, Mice, Transgenic
Journal Title
J Exp Med
Conference Name
Journal ISSN
0022-1007
1540-9538
1540-9538
Volume Title
215
Publisher
Rockefeller University Press
Publisher DOI
Sponsorship
Cancer Research UK (CB4230)
Cancer Research UK (C14303/A17197)
Cancer Research UK (C14303/A17197)