Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.
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Peer-reviewed
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Article
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Abstract
The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory.
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Keywords
genetic engineering, immune evasion, immunological memory, orthopoxviruses, smallpox, vaccine, vaccinia virus, Animals, Communicable Diseases, Emerging, Cytokines, Genetic Engineering, Humans, Immunity, Immunogenicity, Vaccine, Immunologic Memory, Immunomodulation, Inflammation Mediators, Smallpox, Smallpox Vaccine, Vaccinia virus, Viral Vaccines, Zoonoses
Journal Title
Viruses
Conference Name
Journal ISSN
1999-4915
1999-4915
1999-4915
Volume Title
10
Publisher
MDPI AG
Publisher DOI
Sponsorship
Wellcome Trust (090315/Z/09/Z)
Wellcome Trust (090315/B/09/A)
Wellcome Trust (090315/B/09/A)