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dc.contributor.authorKhandaker, Golam
dc.date.accessioned2018-05-16T10:32:31Z
dc.date.available2018-05-16T10:32:31Z
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275837
dc.description.abstractLow-grade inflammation is a risk factor for depression, psychosis and other major psychiatric disorders. It is associated with poor response to antidepressant and antipsychotics, and could potentially be a treatment target. However, there is limited data on the prevalence of low-grade inflammation in major psychiatric disorders, and on the characteristics of patients who show evidence of inflammation. We examined the prevalence of low-grade inflammation, and associated sociodemographic and clinical factors in acute psychiatric inpatients. An anonymised search of the electronic patient records of Cambridgeshire and Peterborough NHS Foundation Trust was used to identify patients aged 18 to 65 years who were hospitalised between 2013 and 2016 (inclusive). We excluded patients on antibiotics or oral steroids, or with missing data. Inflammation was defined using serum C-reactive protein (>3mg/L) or total white cell count (>9.4 x 109/L) as measured within 14 days of admission. Out of all 599 admissions, the prevalence of inflammation (serum CRP >3mg/L) in the ICD-10 diagnostic groups of psychotic disorders (F20-29), mood disorders (F30-39), neurotic disorders (F40-48) and personality disorders (F60-69) was 32%, 21%, 22% and 42%, respectively. In multivariable analyses, low-grade inflammation was associated with older age, black ethnicity, being single, self-harm, diagnoses of schizophrenia, bipolar disorder, current treatments with antidepressants, benzodiazepines, and with current treatment for medical comorbidities. A notable proportion of acutely unwell psychiatric patients from all ICD-10 major diagnostic groups show evidence of low-grade inflammation, suggesting inflammation may be relevant for all psychiatric disorders.
dc.description.sponsorshipGMK is supported by an Intermediate Clinical Fellowship from the Wellcome Trust (201486/Z/16/Z) and a Clinical Lecturer Starter Grant from the Academy of Medical Sciences, UK (grant no. 80354). PBJ acknowledges grant support from the Wellcome Trust (095844/Z/11/Z & 088869/Z/09/Z) and NIHR (RP-PG-0616-20003 and the Collaboration for Leadership in Applied Health Research & Care (CLAHRC) East of England).
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectpsychosis
dc.subjectdepression
dc.subjectCRP
dc.subjectinflammation
dc.subjectwhite cell count
dc.subjectimmunopsychiatry
dc.titlePrevalence and Correlates of Low-Grade Systemic Inflammation in Adult Psychiatric Inpatients: an electronic health record-based study
dc.typeArticle
prism.publicationNamePsychoneuroendocrinology
dc.identifier.doi10.17863/CAM.23104
dcterms.dateAccepted2018-02-27
rioxxterms.versionofrecord10.1016/j.psyneuen.2018.02.031
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-02-27
dc.contributor.orcidKhandaker, Golam [0000-0002-4935-9220]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idAcademy of Medical Sciences (unknown)
pubs.funder-project-idWellcome Trust (201486/Z/16/Z)
cam.issuedOnline2018-03-01
cam.orpheus.successThu Jan 30 12:59:27 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International