Show simple item record

dc.contributor.authorHulman, Adamen
dc.contributor.authorSimmons, Rebeccaen
dc.contributor.authorVistisen, Dorteen
dc.contributor.authorTabák, Adam Gen
dc.contributor.authorDekker, Jacqueline Men
dc.contributor.authorAlssema, Marjanen
dc.contributor.authorRutters, Femkeen
dc.contributor.authorKoopman, Anitra DMen
dc.contributor.authorSolomon, Thomas PJen
dc.contributor.authorKirwan, John Pen
dc.contributor.authorHansen, Torbenen
dc.contributor.authorJonsson, Annaen
dc.contributor.authorGjesing, Anette Prioren
dc.contributor.authorEiberg, Hansen
dc.contributor.authorAstrup, Arneen
dc.contributor.authorPedersen, Olufen
dc.contributor.authorSørensen, Thorkild IAen
dc.contributor.authorWitte, Daniel Ren
dc.contributor.authorFærch, Kristineen
dc.date.accessioned2018-05-16T17:11:53Z
dc.date.available2018-05-16T17:11:53Z
dc.date.issued2017-02-01en
dc.identifier.issn1355-008X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275856
dc.description.abstractWe aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response curve groups. We analyzed data from 1,267 individuals without diabetes from five studies in Denmark, the Netherlands and the USA. Each study included between 5 and 11 measurements at different time points during a 2-h oral glucose tolerance test, resulting in 9,602 plasma glucose measurements. Latent class trajectories with a cubic specification for time were fitted to identify different patterns of plasma glucose change during the oral glucose tolerance test. Cardiometabolic risk factor profiles were compared between the identified groups. Using latent class trajectory analysis, five glucose response curves were identified. Despite similar fasting and 2-h values, glucose peaks and peak times varied greatly between groups, ranging from 7-12 mmol/L, and 35-70 min. The group with the lowest and earliest plasma glucose peak had the lowest estimated cardiovascular risk, while the group with the most delayed plasma glucose peak and the highest 2-h value had the highest estimated risk. One group, with normal fasting and 2-h values, exhibited an unusual profile, with the highest glucose peak and the highest proportion of smokers and men. The heterogeneity in glucose response curves and the distinct cardiometabolic risk profiles may reflect different underlying physiologies. Our results warrant more detailed studies to identify the source of the heterogeneity across the different phenotypes and whether these differences play a role in the development of type 2 diabetes and cardiovascular disease.
dc.description.sponsorshipA.H., R.K.S. and D.R.W. are supported by the Danish Diabetes Academy. The Danish Diabetes Academy is funded by the Novo Nordisk Foundation.
dc.languageengen
dc.publisherSpringer
dc.subjectoral glucose tolerance testen
dc.subjectgGlucose response curveen
dc.subjectcardiometabolic risken
dc.subjectlatent class trajectory analysisen
dc.titleHeterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk.en
dc.typeArticle
prism.endingPage434
prism.issueIdentifier2en
prism.publicationDate2017en
prism.publicationNameEndocrineen
prism.startingPage427
prism.volume55en
dc.identifier.doi10.17863/CAM.23127
dcterms.dateAccepted2016-09-14en
rioxxterms.versionofrecord10.1007/s12020-016-1126-zen
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-02-01en
dc.contributor.orcidSimmons, Rebecca [0000-0002-7726-8529]
dc.identifier.eissn1559-0100
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2016-10-03en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record