Default Mode Network Engagement Beyond Self-Referential Internal Mentation.
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Publication Date
2018-05Journal Title
Brain Connect
ISSN
2158-0014
Publisher
Mary Ann Liebert Inc
Volume
8
Issue
4
Pages
245-253
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Vatansever, D., Manktelow, A., Sahakian, B., Menon, D., & Stamatakis, E. (2018). Default Mode Network Engagement Beyond Self-Referential Internal Mentation.. Brain Connect, 8 (4), 245-253. https://doi.org/10.1089/brain.2017.0489
Abstract
The default mode network (DMN) is typically associated with off-task internal mentation, or with goal-oriented tasks that require self-referential processing such as autobiographical planning. However, recent reports suggest a broader involvement of the DMN in higher cognition. In line with this view, we report global connectivity changes that are centered on the main DMN hubs of precuneus and posterior cingulate cortex during a functional magnetic resonance imaging-based visuospatial version of the Tower of London planning task. Importantly, functional connectivity of these regions with the left caudate shows a significant relationship with faster reaction time to correct responses only during the high-demand planning condition, thus offering further evidence for the DMN's engagement during visuospatial planning. The results of this study not only provide robust evidence against the widely held notion of DMN disengagement during goal-oriented, attention-demanding, externally directed tasks but also support its involvement in a broader cognitive context with a memory-related role that extends beyond self-referential, internally directed mentation.
Keywords
Brain, Neural Pathways, Humans, Oxygen, Magnetic Resonance Imaging, Brain Mapping, Mental Processes, Models, Neurological, Image Processing, Computer-Assisted, Adult, Middle Aged, Female, Male
Sponsorship
Department of Health (via National Institute for Health Research (NIHR)) (unknown)
Identifiers
External DOI: https://doi.org/10.1089/brain.2017.0489
This record's URL: https://www.repository.cam.ac.uk/handle/1810/275874
Rights
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http://www.rioxx.net/licenses/all-rights-reserved
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