The motor and cognitive features of Parkinson's disease in patients with concurrent Gaucher disease over 2 years: a case series.
Accepted version
Peer-reviewed
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Article
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Authors
Collins, Lucy M
Williams-Gray, Caroline H
Morris, Elizabeth
Deegan, Patrick
Cox, Timothy M
Abstract
We report the cognitive features and progression of Parkinson's disease (PD) in five patients with concurrent Gaucher disease. The patients presented at an earlier age than patients with sporadic PD, as previously noted by others; but in contrast to many previous reports, our patients followed a variable clinical course. While two patients developed early cognitive deficits and dementia, three others remained cognitively intact over the follow-up period. Thus, in this small case series, PD in the context of GD more closely resembles idiopathic PD in terms of its clinical heterogeneity in contrast to PD associated with GBA heterozygote mutations.
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Keywords
Cognitive function, GBA mutations, Gaucher Disease, Parkinson's Disease, Aged, Cognition, Cognitive Dysfunction, Dementia, Disease Progression, Female, Follow-Up Studies, Gaucher Disease, Humans, Male, Middle Aged, Parkinson Disease
Journal Title
J Neurol
Conference Name
Journal ISSN
0340-5354
1432-1459
1432-1459
Volume Title
265
Publisher
Springer Science and Business Media LLC
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Sponsorship
Cure Parkinson's Trust (RVG9R- p137)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
NIHR BRC and NIHR Senior Investigator, Rosetrees funding