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dc.contributor.authorKuscu, Murat
dc.contributor.authorAkan, Ozgur B
dc.date.accessioned2018-05-25T13:07:21Z
dc.date.available2018-05-25T13:07:21Z
dc.date.issued2018
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276210
dc.description.abstractWe consider a microfluidic molecular communication (MC) system, where the concentration-encoded molecular messages are transported via fluid flow-induced convection and diffusion, and detected by a surface-based MC receiver with ligand receptors placed at the bottom of the microfluidic channel. The overall system is a convection-diffusion-reaction system that can only be solved by numerical methods, e.g., finite element analysis (FEA). However, analytical models are key for the information and communication technology (ICT), as they enable an optimisation framework to develop advanced communication techniques, such as optimum detection methods and reliable transmission schemes. In this direction, we develop an analytical model to approximate the expected time course of bound receptor concentration, i.e., the received signal used to decode the transmitted messages. The model obviates the need for computationally expensive numerical methods by capturing the nonlinearities caused by laminar flow resulting in parabolic velocity profile, and finite number of ligand receptors leading to receiver saturation. The model also captures the effects of reactive surface depletion layer resulting from the mass transport limitations and moving reaction boundary originated from the passage of finite-duration molecular concentration pulse over the receiver surface. Based on the proposed model, we derive closed form analytical expressions that approximate the received pulse width, pulse delay and pulse amplitude, which can be used to optimize the system from an ICT perspective. We evaluate the accuracy of the proposed model by comparing model-based analytical results to the numerical results obtained by solving the exact system model with COMSOL Multiphysics.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMicrofluidics
dc.subjectSurface Properties
dc.subjectFinite Element Analysis
dc.subjectNanotechnology
dc.subjectModels, Theoretical
dc.subjectInternet
dc.titleModeling convection-diffusion-reaction systems for microfluidic molecular communications with surface-based receivers in Internet of Bio-Nano Things.
dc.typeArticle
prism.issueIdentifier2
prism.publicationDate2018
prism.publicationNamePLoS One
prism.startingPagee0192202
prism.volume13
dc.identifier.doi10.17863/CAM.23490
dcterms.dateAccepted2018-01-12
rioxxterms.versionofrecord10.1371/journal.pone.0192202
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidKuscu, Murat [0000-0002-8463-6027]
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (616922)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (665564)
cam.issuedOnline2018-02-07


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International