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dc.contributor.authorSmith, Gordonen
dc.date.accessioned2018-06-01T12:03:50Z
dc.date.available2018-06-01T12:03:50Z
dc.date.issued2018-05en
dc.identifier.issn1521-6934
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276442
dc.description.abstractFetal growth restriction (FGR) is a major cause of morbidity and mortality. Clinical methods for identifying women whose pregnancies are affected by FGR do not perform well. Despite this, the current approach to screening remains clinical assessment of risk and targeted use of ultrasound. Universal screening of women using ultrasound has not been shown to improve outcomes in randomised controlled trials and, when implemented nationally in France, appeared mostly to change outcomes for the worse through the effect of iatrogenic prematurity on false positives. Research is currently focused on trying to develop screening tests with higher sensitivity and specificity, for example by combining ultrasound with placental biomarkers. The diagnostic tests employed should be identified through high-quality research investigating the diagnostic accuracy of the tests, and this will usually involve blinding of the results. Therefore, future trials of screening and intervention will require careful planning. Moreover, if trials are to be powered for perinatal death large sample sizes will be required.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.subjectPlacentaen
dc.subjectHumansen
dc.subjectFetal Growth Retardationen
dc.subjectUltrasonography, Prenatalen
dc.subjectMass Screeningen
dc.subjectPrenatal Careen
dc.subjectRisk Factorsen
dc.subjectPredictive Value of Testsen
dc.subjectBiometryen
dc.subjectGestational Ageen
dc.subjectPregnancyen
dc.subjectResearch Designen
dc.subjectInfant, Newbornen
dc.subjectFemaleen
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectBiomarkersen
dc.titleUniversal screening for foetal growth restriction.en
dc.typeArticle
prism.endingPage28
prism.publicationDate2018en
prism.publicationNameBest practice & research. Clinical obstetrics & gynaecologyen
prism.startingPage16
prism.volume49en
dc.identifier.doi10.17863/CAM.23745
dcterms.dateAccepted2018-02-15en
rioxxterms.versionofrecord10.1016/j.bpobgyn.2018.02.008en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-05en
dc.contributor.orcidSmith, Gordon [0000-0003-2124-0997]
dc.identifier.eissn1532-1932
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
rioxxterms.freetoread.startdate2019-02-27


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