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Addressing the estimation of standard errors in fixed effects meta-analysis.

Published version
Peer-reviewed

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Authors

Domínguez Islas, Clara  ORCID logo  https://orcid.org/0000-0003-0653-3441
Rice, Kenneth M 

Abstract

Standard methods for fixed effects meta-analysis assume that standard errors for study-specific estimates are known, not estimated. While the impact of this simplifying assumption has been shown in a few special cases, its general impact is not well understood, nor are general-purpose tools available for inference under more realistic assumptions. In this paper, we aim to elucidate the impact of using estimated standard errors in fixed effects meta-analysis, showing why it does not go away in large samples and quantifying how badly miscalibrated standard inference will be if it is ignored. We also show the important role of a particular measure of heterogeneity in this miscalibration. These developments lead to confidence intervals for fixed effects meta-analysis with improved performance for both location and scale parameters.

Description

Keywords

fixed effects, heterogeneity, meta-analysis, random effects, Biostatistics, Common Cold, Computer Simulation, Humans, Meta-Analysis as Topic, Models, Statistical, Systematic Reviews as Topic, Zinc

Journal Title

Stat Med

Conference Name

Journal ISSN

0277-6715
1097-0258

Volume Title

37

Publisher

Wiley
Sponsorship
MRC (unknown)