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dc.contributor.authorHorne, Hisani N
dc.contributor.authorOh, Hannah
dc.contributor.authorSherman, Mark E
dc.contributor.authorPalakal, Maya
dc.contributor.authorHewitt, Stephen M
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorMilne, Roger L
dc.contributor.authorHardisson, David
dc.contributor.authorBenitez, Javier
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorBrenner, Hermann
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorCora, Renata
dc.contributor.authorCouch, Fergus J
dc.contributor.authorCuk, Katarina
dc.contributor.authorDevilee, Peter
dc.contributor.authorEaston, Douglas F
dc.contributor.authorEccles, Diana M
dc.contributor.authorEilber, Ursula
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorHeikkilä, Päivi
dc.contributor.authorHolleczek, Bernd
dc.contributor.authorHooning, Maartje J
dc.contributor.authorJones, Michael
dc.contributor.authorKeeman, Renske
dc.contributor.authorMannermaa, Arto
dc.contributor.authorMartens, John WM
dc.contributor.authorMuranen, Taru A
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorOlson, Janet E
dc.contributor.authorOrr, Nick
dc.contributor.authorPerez, Jose IA
dc.contributor.authorPharoah, Paul DP
dc.contributor.authorRuddy, Kathryn J
dc.contributor.authorSaum, Kai-Uwe
dc.contributor.authorSchoemaker, Minouk J
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorSironen, Reijo
dc.contributor.authorSmit, Vincent THBM
dc.contributor.authorSwerdlow, Anthony J
dc.contributor.authorTengström, Maria
dc.contributor.authorThomas, Abigail S
dc.contributor.authorTimmermans, A Mieke
dc.contributor.authorTollenaar, Rob AEM
dc.contributor.authorTroester, Melissa A
dc.contributor.authorvan Asperen, Christi J
dc.contributor.authorvan Deurzen, Carolien HM
dc.contributor.authorVan Leeuwen, Flora F
dc.contributor.authorVan't Veer, Laura J
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorFigueroa, Jonine D
dc.date.accessioned2018-06-05T13:16:47Z
dc.date.available2018-06-05T13:16:47Z
dc.date.issued2018-04-26
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276619
dc.description.abstractE-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectReceptor, erbB-2
dc.subjectCadherins
dc.subjectReceptors, Estrogen
dc.subjectReceptors, Progesterone
dc.subjectPrognosis
dc.subjectProportional Hazards Models
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectGene Expression
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectBiomarkers, Tumor
dc.titleE-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage6574
prism.volume8
dc.identifier.doi10.17863/CAM.23920
dcterms.dateAccepted2018-03-16
rioxxterms.versionofrecord10.1038/s41598-018-23733-4
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-04-26
dc.contributor.orcidMilne, Roger L [0000-0001-5764-7268]
dc.contributor.orcidHardisson, David [0000-0002-2183-3699]
dc.contributor.orcidEaston, Douglas F [0000-0003-2444-3247]
dc.contributor.orcidMartens, John WM [0000-0002-3428-3366]
dc.contributor.orcidNevanlinna, Heli [0000-0002-0916-2976]
dc.contributor.orcidPharoah, Paul DP [0000-0001-8494-732X]
dc.contributor.orcidFigueroa, Jonine D [0000-0002-5100-623X]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research UK (A16563)
pubs.funder-project-idCancer Research UK (A10118)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (634935)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (633784)
pubs.funder-project-idEuropean Commission (223175)
cam.issuedOnline2018-04-26
cam.orpheus.successThu Jan 30 12:59:39 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International