Ventral Striatal D2/3 Receptor Availability Is Associated with Impulsive Choice Behavior As Well As Limbic Corticostriatal Connectivity.
Niessen, Heiko G
The international journal of neuropsychopharmacology
Oxford University Press
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Barlow, R. L., Gorges, M., Wearn, A., Niessen, H. G., Kassubek, J., Dalley, J., & Pekcec, A. (2018). Ventral Striatal D2/3 Receptor Availability Is Associated with Impulsive Choice Behavior As Well As Limbic Corticostriatal Connectivity.. The international journal of neuropsychopharmacology, 21 (7), 705-715. https://doi.org/10.1093/ijnp/pyy030
BACKGROUND: Low dopamine D2/3 receptor availability in the nucleus accumbens (NAcb) shell is associated with highly-impulsive behavior in rats, as measured by premature responses in a cued attentional task. However, it is unclear whether dopamine D2/3 receptor availability in the NAcb is equally linked to intolerance for delayed rewards, a related form of impulsivity. METHODS: We investigated the relationship between D2/3 receptor availability in the NAcb and impulsivity in a delay-discounting task (DDT) where animals must choose between immediate small- magnitude rewards and delayed larger-magnitude rewards. Corticostriatal D2/3 receptor availability was measured in rats stratified for high-, and low-impulsivity using in-vivo [18F]fallypride positron emission tomography (PET) and ex-vivo [3H]raclopride autoradiography. Resting-state functional connectivity in limbic corticostriatal networks was also assessed using fMRI. RESULTS: DDT impulsivity was inversely related to D2/3 receptor availability in the NAcb core but not the dorsal striatum with higher D2/3 binding in the NAcb shell of high-impulsive rats compared with low- impulsive rats. D2/3 receptor availability was associated with stronger connectivity between the cingulate cortex and hippocampus of high versus low impulsive rats. CONCLUSIONS: We conclude that DDT impulsivity is associated with low D2/3 receptor binding in the NAcb core. Thus two related forms of waiting impulsivity – premature responding and delay intolerance in a delay-of-reward task – implicate an involvement of D2/3 receptor availability in the NAcb shell and core, respectively. This dissociation may be causal or consequential to enhanced functional connectivity of limbic brain circuitry and hold relevance for attention-deficit/hyperactivity disorder, drug addiction and other psychiatric disorders.
Corpus Striatum, Cerebral Cortex, Animals, Rats, Receptors, Dopamine D2, Positron-Emission Tomography, Magnetic Resonance Imaging, Autoradiography, Behavior, Animal, Reward, Male, Receptors, Dopamine D3, Connectome, Delay Discounting
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External DOI: https://doi.org/10.1093/ijnp/pyy030
This record's URL: https://www.repository.cam.ac.uk/handle/1810/276621
Attribution-NonCommercial 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc/4.0/
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