Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C- labeled cell metabolites
Current Opinion in Chemical Biology
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Brindle, K., & Hesketh, R. (2018). Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C- labeled cell metabolites. Current Opinion in Chemical Biology, 45 187-194. https://doi.org/10.1016/j.cbpa.2018.03.004
Hyperpolarization of 13C-labeled substrates can increase their 13C NMR signal by more than 10,000-fold, which has allowed magnetic resonance imaging (MRI) of metabolic reactions in vivo. This has already provided a unique insight into the dysregulated metabolic pathways and microenvironment of tumors. Perhaps the best known of the cancer-associated metabolic abberations is the Warburg effect, which has been imaged in patients using hyperpolarized [1-13C]pyruvate. In clinical oncology there is a requirement to diagnose tumors earlier, better determine their aggressiveness and prognosis, identify novel treatment targets and detect response to treatment earlier. Here we consider some of the hyperpolarized substrates that have been developed and have the potential to meet these requirements and become the precision imaging tools of the future.
imaging, metabolism, magnetic resonance, carbon-13
KMB's lab is supported by a Cancer Research UK Programme grant (17242) and by the CRUK-EPSRC Imaging Centre in Cambridge and Manchester (16465).
Cancer Research UK (CB4100)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (642773)
Cancer Research UK (C14303_do not transfer)
Aarhus University (Source: Data Science Research Centre (DSRC)) (15952)
External DOI: https://doi.org/10.1016/j.cbpa.2018.03.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/276661
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/