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dc.contributor.authorMenon, Daviden
dc.contributor.authorErcole, Arien
dc.date.accessioned2018-06-08T08:25:52Z
dc.date.available2018-06-08T08:25:52Z
dc.date.issued2017-01en
dc.identifier.issn0072-9752
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276745
dc.description.abstractTraumatic brain injury (TBI) is a growing global problem, which is responsible for a substantial burden of disability and death, and which generates substantial healthcare costs. High-quality intensive care can save lives and improve the quality of outcome. TBI is extremely heterogeneous in terms of clinical presentation, pathophysiology, and outcome. Current approaches to the critical care management of TBI are not underpinned by high-quality evidence, and many of the current therapies in use have not shown benefit in randomized control trials. However, observational studies have informed the development of authoritative international guidelines, and the use of multimodality monitoring may facilitate rational approaches to optimizing acute physiology, allowing clinicians to optimize the balance between benefit and risk from these interventions in individual patients. Such approaches, along with the emerging impact of advanced neuroimaging, genomics, and protein biomarkers, could lead to the development of precision medicine approaches to the intensive care management of TBI.
dc.format.mediumPrinten
dc.languageengen
dc.subjectHumansen
dc.subjectCritical Careen
dc.subjectNeuroimagingen
dc.subjectBrain Injuries, Traumaticen
dc.titleCritical care management of traumatic brain injury.en
dc.typeArticle
prism.endingPage274
prism.publicationDate2017en
prism.publicationNameHandbook of clinical neurologyen
prism.startingPage239
prism.volume140en
dc.identifier.doi10.17863/CAM.24039
dcterms.dateAccepted2016-07-14en
rioxxterms.versionofrecord10.1016/b978-0-444-63600-3.00014-3en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-01en
dc.contributor.orcidMenon, David [0000-0002-3228-9692]
dc.contributor.orcidErcole, Ari [0000-0001-8350-8093]
dc.identifier.eissn2212-4152
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEC FP7 CP (602150)
rioxxterms.freetoread.startdate2018-02-07


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