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dc.contributor.authorRemes, Oliviaen
dc.contributor.authorWainwright, Nicholasen
dc.contributor.authorSurtees, Paulen
dc.contributor.authorLafortune, Louiseen
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorBrayne, Carolen
dc.date.accessioned2018-06-12T08:16:18Z
dc.date.available2018-06-12T08:16:18Z
dc.date.issued2018-10-27en
dc.identifier.issn2044-6055
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276885
dc.description.abstractABSTRACT OBJECTIVE Generalized anxiety disorder (GAD) is the most common anxiety disorder in the general population, and has been associated with high economic and human burden. However, it has been neglected in the health services literature. The objective of this study will be to assess whether GAD leads to non-psychiatric hospital admissions using data from the European Prospective Investigation of Cancer-Norfolk. Other aims include determining whether early or late onset forms of the disorder, episode chronicity and frequency, and comorbidity with major depressive disorder (MDD) contribute to non-psychiatric hospital admissions. DESIGN Large, population study. SETTING UK population-based cohort. PARTICIPANTS 30,445 people over the age of 40 were recruited through general practice registers in England. Of these, 20,919 completed a structured health and lifestyle questionnaire used to assess GAD. Anxiety was examined in 1996-2000, and health service use was captured between 1999/00 and 2009 through record linkage with large, administrative health databases. 17,939 participants had complete data on covariates. MAIN OUTCOME MEASURE Past-year GAD defined according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. RESULTS In this study, 2.2% (393/17,939) respondents had GAD. Anxiety was not independently associated with non-psychiatric hospital admissions (IRR=1.04, 95% CI: 0.90, 1.20) over nine years. However, those whose anxiety was comorbid with depression showed a statistically significantly increased risk for non-psychiatric hospital admissions (IRR=1.23, 95% CI: 1.02, 1.49). CONCLUSION People with GAD and MDD comorbidity were at an increased risk for hospital admissions. Clinicians should consider that meeting criteria for a pure or individual disorder at one point in time, such as past-year GAD does not necessarily predict deleterious health outcomes; rather different forms of the disorder, such as comorbid cases might be of greater importance. Key words: Anxiety, anxiety disorders, health services
dc.format.mediumElectronicen
dc.languageengen
dc.publisherBMJ Journals
dc.subjectHumansen
dc.subjectPatient Admissionen
dc.subjectRegistriesen
dc.subjectLongitudinal Studiesen
dc.subjectProspective Studiesen
dc.subjectAnxiety Disordersen
dc.subjectDepressive Disorder, Majoren
dc.subjectComorbidityen
dc.subjectAge Distributionen
dc.subjectSex Distributionen
dc.subjectDiagnostic and Statistical Manual of Mental Disordersen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectEnglanden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectSelf Reporten
dc.titleGeneralised anxiety disorder and hospital admissions: findings from a large, population cohort study.en
dc.typeArticle
prism.issueIdentifier10en
prism.publicationDate2018en
prism.publicationNameBMJ openen
prism.startingPagee018539
prism.volume8en
dc.identifier.doi10.17863/CAM.24170
dcterms.dateAccepted2017-10-19en
rioxxterms.versionofrecord10.1136/bmjopen-2017-018539en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-10-27en
dc.contributor.orcidLafortune, Louise [0000-0002-9018-1217]
dc.contributor.orcidBrayne, Carol [0000-0001-5307-663X]
dc.identifier.eissn2044-6055
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
cam.orpheus.successThu Jan 30 12:59:39 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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