Cardiovascular adaptation to hypoxia and the role of peripheral resistance.
eLife Sciences Publications Ltd
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Cowburn, A., Macias, D., Summers, C., Chilvers, E., & Johnson, R. (2017). Cardiovascular adaptation to hypoxia and the role of peripheral resistance.. eLife, 6 https://doi.org/10.7554/elife.28755
Systemic vascular pressure in vertebrates is regulated by a range of factors: one key element of control is peripheral resistance in tissue capillary beds. Many aspects of the relationship between central control of vascular flow and peripheral resistance are unclear. An important example of this is the relationship between hypoxic response in individual tissues, and the effect that response has on systemic cardiovascular adaptation to oxygen deprivation. We show here how hypoxic response via the HIF transcription factors in one large vascular bed, that underlying the skin, influences cardiovascular response to hypoxia in mice. We show that the response of the skin to hypoxia feeds back on a wide range of cardiovascular parameters, including heart rate, arterial pressures, and body temperature. These data represent the first demonstration of a dynamic role for oxygen sensing in a peripheral tissue directly modifying cardiovascular response to the challenge of hypoxia.
Animals, Mice, Temperature, Adaptation, Physiological, Blood Pressure, Heart Rate, Vascular Resistance, Skin Physiological Phenomena, Hypoxia
Wellcome Trust (092738/Z/10/Z)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
National Cancer Institute (NCI) (R01CA153983)
European Commission (331756)
Wellcome Trust (214283/Z/18/Z)
External DOI: https://doi.org/10.7554/elife.28755
This record's URL: https://www.repository.cam.ac.uk/handle/1810/276894
Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International