Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians.
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Authors
Oliver-Williams, Clare
Howard, Annie Green
Navas-Acien, Ana
Howard, Barbara V
Franceschini, Nora
Publication Date
2018-06Journal Title
Journal of the American Society of Hypertension : JASH
ISSN
1933-1711
Publisher
Elsevier
Volume
12
Issue
6
Pages
426-437.e9
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Oliver-Williams, C., Howard, A. G., Navas-Acien, A., Howard, B. V., Tellez-Plaza, M., & Franceschini, N. (2018). Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians.. Journal of the American Society of Hypertension : JASH, 12 (6), 426-437.e9. https://doi.org/10.1016/j.jash.2018.03.002
Abstract
American Indian communities are at greater risk of hypertension and cardiovascular disease than the general US population, and are exposed to greater cadmium levels. However, cadmium's effect on blood pressure is unclear. This study assesses the association between baseline urinary cadmium and longitudinal changes in blood pressure in American Indian communities. Cadmium was measured in 3,047 baseline urine samples from Strong Heart Study participants from three geographic areas. Longitudinal changes in blood pressure across three study visits (1989-99) were modelled using linear mixed models by baseline log urinary cadmium to creatinine ratio. Hypertension risk was evaluated using interval-censored survival analysis. Higher levels of urinary cadmium at baseline were associated with faster rates of increase in diastolic and systolic blood pressure (P (trend)=0.001 and 0.02, respectively). The estimated change in diastolic and systolic blood pressures per year was 0.18mmHg (0.05-0.31) and 0.62mmHg (0.37-0.87) in the upper quintile of cadmium level compared to -0.11mmHg (-0.24-0.02) and 0.21mmHg (-0.04-0.46) in the lowest, respectively. A one unit increase in log transformed urinary cadmium was associated with 10% greater hypertension risk (95% confidence interval 1.01-1.20). In conclusion, blood pressure of individuals with greater baseline levels of urinary cadmium increased at a faster rate relative to those with lower levels.
Sponsorship
British Heart Foundation (RE/13/6/30180)
Identifiers
External DOI: https://doi.org/10.1016/j.jash.2018.03.002
This record's URL: https://www.repository.cam.ac.uk/handle/1810/276928
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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