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dc.contributor.authorOliver-Williams, Clareen
dc.contributor.authorHoward, Annie Greenen
dc.contributor.authorNavas-Acien, Anaen
dc.contributor.authorHoward, Barbara Ven
dc.contributor.authorTellez-Plaza, Mariaen
dc.contributor.authorFranceschini, Noraen
dc.date.accessioned2018-06-12T12:56:50Z
dc.date.available2018-06-12T12:56:50Z
dc.date.issued2018-06en
dc.identifier.issn1933-1711
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276928
dc.description.abstractAmerican Indian communities are at greater risk of hypertension and cardiovascular disease than the general US population, and are exposed to greater cadmium levels. However, cadmium's effect on blood pressure is unclear. This study assesses the association between baseline urinary cadmium and longitudinal changes in blood pressure in American Indian communities. Cadmium was measured in 3,047 baseline urine samples from Strong Heart Study participants from three geographic areas. Longitudinal changes in blood pressure across three study visits (1989-99) were modelled using linear mixed models by baseline log urinary cadmium to creatinine ratio. Hypertension risk was evaluated using interval-censored survival analysis. Higher levels of urinary cadmium at baseline were associated with faster rates of increase in diastolic and systolic blood pressure (P (trend)=0.001 and 0.02, respectively). The estimated change in diastolic and systolic blood pressures per year was 0.18mmHg (0.05-0.31) and 0.62mmHg (0.37-0.87) in the upper quintile of cadmium level compared to -0.11mmHg (-0.24-0.02) and 0.21mmHg (-0.04-0.46) in the lowest, respectively. A one unit increase in log transformed urinary cadmium was associated with 10% greater hypertension risk (95% confidence interval 1.01-1.20). In conclusion, blood pressure of individuals with greater baseline levels of urinary cadmium increased at a faster rate relative to those with lower levels.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians.en
dc.typeArticle
prism.endingPage437.e9
prism.issueIdentifier6en
prism.publicationDate2018en
prism.publicationNameJournal of the American Society of Hypertension : JASHen
prism.startingPage426
prism.volume12en
dc.identifier.doi10.17863/CAM.24211
dcterms.dateAccepted2018-03-02en
rioxxterms.versionofrecord10.1016/j.jash.2018.03.002en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-06en
dc.contributor.orcidOliver-Williams, Clare Teresa [0000-0002-3573-2426]
dc.contributor.orcidTellez-Plaza, Maria [0000-0002-3850-1228]
dc.identifier.eissn1878-7436
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (RE/13/6/30180)
rioxxterms.freetoread.startdate2019-03-10


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Attribution-NonCommercial-NoDerivatives 4.0 International
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