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dc.contributor.authorSun, Benen
dc.contributor.authorMaranville, Joseph Cen
dc.contributor.authorPeters, Jamesen
dc.contributor.authorStacey, Daviden
dc.contributor.authorStaley, Jamesen
dc.contributor.authorBlackshaw, Jamesen
dc.contributor.authorBurgess, Stephenen
dc.contributor.authorJiang, Taoen
dc.contributor.authorPaige, Ellieen
dc.contributor.authorSurendran, Praveenen
dc.contributor.authorOliver-Williams, Clareen
dc.contributor.authorKamat, Mihir Aen
dc.contributor.authorPrins, Bramen
dc.contributor.authorWilcox, Sheri Ken
dc.contributor.authorZimmerman, Erik Sen
dc.contributor.authorChi, Anen
dc.contributor.authorBansal, Narinderen
dc.contributor.authorSpain, Sarah Len
dc.contributor.authorWood, Angelaen
dc.contributor.authorMorrell, Nicholasen
dc.contributor.authorBradley, Johnen
dc.contributor.authorJanjic, Nebojsaen
dc.contributor.authorRoberts, David Jen
dc.contributor.authorOuwehand, Willemen
dc.contributor.authorTodd, John Aen
dc.contributor.authorSoranzo, Nicoleen
dc.contributor.authorSuhre, Karstenen
dc.contributor.authorPaul, Dirken
dc.contributor.authorFox, Caroline Sen
dc.contributor.authorPlenge, Robert Men
dc.contributor.authorDanesh, Johnen
dc.contributor.authorRunz, Heikoen
dc.contributor.authorButterworth, Adamen
dc.date.accessioned2018-06-12T14:33:47Z
dc.date.available2018-06-12T14:33:47Z
dc.date.issued2018-06-06en
dc.identifier.issn0028-0836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276952
dc.description.abstract51 Although proteins are the primary functional units of biology and the direct targets of most 52 drugs, there is limited knowledge of the genetic factors determining inter-individual variation 53 in protein levels. Here we reveal the genetic architecture of the human plasma proteome. We 54 identify 1,927 genetic associations with 1,478 proteins, a 4-fold increase on existing 55 knowledge, including trans associations for 1,104 proteins. To understand consequences of 56 perturbations in plasma protein levels, we apply an integrated approach that links genetic 57 variation with biological pathway, disease, and drug databases. We provide insights into 58 pathobiology by uncovering the molecular effects of disease-associated variants and 59 identifying causal roles for protein biomarkers in disease through Mendelian randomisation 60 analysis. Our results reveal new drug targets, opportunities for matching existing drugs with 61 new disease indications, and potential safety concerns for drugs under development.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.subjectHumansen
dc.subjectInflammatory Bowel Diseasesen
dc.subjectVasculitisen
dc.subjectHepatocyte Growth Factoren
dc.subjectBlood Proteinsen
dc.subjectalpha 1-Antitrypsinen
dc.subjectProto-Oncogene Proteinsen
dc.subjectProteomeen
dc.subjectGenomicsen
dc.subjectMutation, Missenseen
dc.subjectQuantitative Trait Locien
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectMyeloblastinen
dc.subjectPositive Regulatory Domain I-Binding Factor 1en
dc.titleGenomic atlas of the human plasma proteome.en
dc.typeArticle
prism.endingPage79
prism.issueIdentifier7708en
prism.publicationDate2018en
prism.publicationNameNatureen
prism.startingPage73
prism.volume558en
dc.identifier.doi10.17863/CAM.24232
dcterms.dateAccepted2018-04-27en
rioxxterms.versionofrecord10.1038/s41586-018-0175-2en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-06-06en
dc.contributor.orcidSun, Ben [0000-0001-6347-2281]
dc.contributor.orcidBlackshaw, James [0000-0002-0343-0319]
dc.contributor.orcidBurgess, Stephen [0000-0001-5365-8760]
dc.contributor.orcidSurendran, Praveen [0000-0002-4911-6077]
dc.contributor.orcidOliver-Williams, Clare [0000-0002-3573-2426]
dc.contributor.orcidPrins, Bram [0000-0001-5774-034X]
dc.contributor.orcidBansal, Narinder [0000-0002-6925-1719]
dc.contributor.orcidWood, Angela [0000-0002-7937-304X]
dc.contributor.orcidMorrell, Nicholas [0000-0001-5700-9792]
dc.contributor.orcidBradley, John [0000-0002-7774-8805]
dc.contributor.orcidOuwehand, Willem [0000-0002-7744-1790]
dc.contributor.orcidSoranzo, Nicole [0000-0003-1095-3852]
dc.contributor.orcidSuhre, Karsten [0000-0001-9638-3912]
dc.contributor.orcidPaul, Dirk [0000-0002-8230-0116]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.identifier.eissn1476-4687
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_qA137933)
pubs.funder-project-idMRC (MR/J006599/1)
pubs.funder-project-idMRC (MR/J006602/1)
pubs.funder-project-idBritish Heart Foundation (via Newcastle University) (AJS/JFA/RES/0146/7211)
pubs.funder-project-idBritish Heart Foundation (SP/08/007/23628)
pubs.funder-project-idWellcome Trust (084711/Z/08/Z)
pubs.funder-project-idBritish Heart Foundation (SP/02/002)
pubs.funder-project-idBritish Heart Foundation (FS/06/025)
pubs.funder-project-idMRC (MR/J015709/1)
pubs.funder-project-idEuropean Research Council (268834)
pubs.funder-project-idEuropean Commission (279233)
pubs.funder-project-idNational Institute of Neurological Disorders and Stroke (NINDS) (R21NS064908)
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC 2012-2017)
pubs.funder-project-idNHS Blood and Transplant (NHSBT) (11-01-GEN)
pubs.funder-project-idEC FP7 CP (279143)
pubs.funder-project-idNHS Blood and Transplant (NHSBT) (WP12-01)
pubs.funder-project-idUme� University (unknown)
pubs.funder-project-idUniversity of Sheffield (R/130423)
pubs.funder-project-idMRC (MR/P013880/1)
pubs.funder-project-idBritish Heart Foundation (CH/12/2/29428)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
pubs.funder-project-idEuropean Commission and European Federation of Pharmaceutical Industries and Associations (EFPIA) FP7 Innovative Medicines Initiative (IMI) (116074)
pubs.funder-project-idMRC (MR/P02811X/1)
pubs.funder-project-idMRC (via University of Leicester) (MR/M012816/1)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idBritish Heart Foundation (RG/16/4/32218)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (3819-1617-25)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NIHR BTRU-2014-10024)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (3819-1516-29)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idMRC (1508647)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMRC (MR/S004068/1)
pubs.funder-project-idMRC (MR/S003746/1)
pubs.funder-project-idMedical Research Council (MC_UU_00002/7)
pubs.funder-project-idBritish Heart Foundation (SP/12/12/29836)
rioxxterms.freetoread.startdate2018-12-06


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