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dc.contributor.authorPatterson, Richard
dc.contributor.authorMcNamara, Eoin
dc.contributor.authorTainio, Marko
dc.contributor.authorde Sá, Thiago Hérick
dc.contributor.authorSmith, Andrea D
dc.contributor.authorSharp, Stephen J
dc.contributor.authorEdwards, Phil
dc.contributor.authorWoodcock, James
dc.contributor.authorBrage, Søren
dc.contributor.authorWijndaele, Katrien
dc.date.accessioned2018-06-13T10:01:34Z
dc.date.available2018-06-13T10:01:34Z
dc.date.issued2018-09
dc.identifier.issn0393-2990
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276983
dc.description.abstractPURPOSE:  To estimate the strength and shape of the dose-response relationship between sedentary behaviour and all-cause, cardiovascular disease (CVD) and cancer mortality, and incident type 2 diabetes (T2D), adjusted for physical activity (PA). Data Sources: Pubmed, Web of Knowledge, Medline, Embase, Cochrane Library and Google Scholar (through September-2016); reference lists. Study Selection: Prospective studies reporting associations between total daily sedentary time or TV viewing time, and ≥ one outcome of interest. Data Extraction: Two independent reviewers extracted data, study quality was assessed; corresponding authors were approached where needed. Data Synthesis: Thirty-four studies (1,331,468 unique participants; good study quality) covering 8 exposure-outcome combinations were included. For total sedentary behaviour, the PA-adjusted relationship was non-linear for all-cause mortality (RR per 1 h/day: were 1.01 (1.00-1.01) ≤ 8 h/day; 1.04 (1.03-1.05) > 8 h/day of exposure), and for CVD mortality (1.01 (0.99-1.02) ≤ 6 h/day; 1.04 (1.03-1.04) > 6 h/day). The association was linear (1.01 (1.00-1.01)) with T2D and non-significant with cancer mortality. Stronger PA-adjusted associations were found for TV viewing (h/day); non-linear for all-cause mortality (1.03 (1.01-1.04) ≤ 3.5 h/day; 1.06 (1.05-1.08) > 3.5 h/day) and for CVD mortality (1.02 (0.99-1.04) ≤ 4 h/day; 1.08 (1.05-1.12) > 4 h/day). Associations with cancer mortality (1.03 (1.02-1.04)) and T2D were linear (1.09 (1.07-1.12)). CONCLUSIONS:  Independent of PA, total sitting and TV viewing time are associated with greater risk for several major chronic disease outcomes. For all-cause and CVD mortality, a threshold of 6-8 h/day of total sitting and 3-4 h/day of TV viewing was identified, above which the risk is increased.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectCardiovascular Diseases
dc.subjectDiabetes Mellitus, Type 2
dc.subjectExercise
dc.subjectTime Factors
dc.subjectTelevision
dc.subjectFemale
dc.subjectMale
dc.subjectSedentary Behavior
dc.titleSedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis.
dc.typeArticle
prism.endingPage829
prism.issueIdentifier9
prism.publicationDate2018
prism.publicationNameEur J Epidemiol
prism.startingPage811
prism.volume33
dc.identifier.doi10.17863/CAM.24261
dcterms.dateAccepted2018-03-12
rioxxterms.versionofrecord10.1007/s10654-018-0380-1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
dc.contributor.orcidPatterson, Richard [0000-0002-8563-6053]
dc.identifier.eissn1573-7284
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idWellcome Trust (087636/Z/08/Z)
pubs.funder-project-idEconomic and Social Research Council (ES/G007462/1)
pubs.funder-project-idMedical Research Council (MR/K023187/1)
pubs.funder-project-idMedical Research Council (MR/P02663X/1)
pubs.funder-project-idMedical Research Council (MR/P024408/1)
pubs.funder-project-idWorld Resources Institute (Unknown)
cam.issuedOnline2018-03-28
cam.orpheus.successThu Jan 30 12:58:20 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Except where otherwise noted, this item's licence is described as Attribution 4.0 International