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Physical activity, sedentary time and gain in overall and central body fat: 7-year follow-up of the ProActive trial cohort.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Golubic, R 
Sharp, SJ 
Simmons, RK 
Griffin, SJ 

Abstract

OBJECTIVE: The objective of this study is to examine the independent associations of time spent in moderate-to-vigorous physical activity (MVPA) and sedentary (SED-time), with total and abdominal body fat (BF), and the bidirectionality of these associations in adults at high risk of type 2 diabetes. DESIGN AND SUBJECTS: We measured MVPA (min per day) and SED-time (h per day) by accelerometry, and indices of total (body weight, fat mass (FM), BF% and FM index) and abdominal BF (waist circumference (WC)) using standard procedures in 231 adults (41.3 ± 6.4 years) with parental history of type 2 diabetes (ProActive UK) at baseline, 1-year and 7-year follow-up. Mixed effects models were used to quantify the independent associations (expressed as standardised β-coefficients (95% confidence interval (CI))) of MVPA and SED-time with fat indices, using data from all three time points. All models were adjusted for age, sex, intervention arm, monitor wear time, follow-up time, smoking status, socioeconomic status and MVPA/SED-time. RESULTS: MVPA was inversely and independently associated with all indices of total BF (for example, 1 s.d. higher MVPA was associated with a reduction in FM, β = -0.09 (95% CI: -0.14, -0.04) s.d.) and abdominal BF (for example, WC: β = -0.07 (-0.12, -0.02)). Similarly, higher fat indices were independently associated with a reduction in MVPA (for example, WC: β = -0.25 (-0.36, -0.15); FM: β = -0.27 (-0.36, -0.18)). SED-time was positively and independently associated with most fat indices (for example, WC: β = 0.03 (-0.04, 0.09); FM: β = 0.10 (0.03, 0.17)). Higher values of all fat indices independently predicted longer SED-time (for example, WC: β = 0.10 (0.02, 0.18), FM: β = 0.15 (0.07, 0.22)). CONCLUSIONS: The associations of MVPA and SED-time with total and abdominal BF are bidirectional and independent among individuals at high risk for type 2 diabetes. The association between BF and MVPA is stronger than the reciprocal association, highlighting the importance of considering BF as a determinant of decreasing activity and a potential consequence. Promoting more MVPA and less SED-time may reduce total and abdominal BF.

Description

Keywords

Accelerometry, Adiposity, Adult, Cardiovascular Diseases, Cohort Studies, Diabetes Mellitus, Type 2, Evidence-Based Medicine, Exercise, Female, Follow-Up Studies, Health Knowledge, Attitudes, Practice, Health Promotion, Humans, Male, Obesity, Risk Factors, Sedentary Behavior, Time Factors, Waist Circumference, Weight Gain

Journal Title

Int J Obes (Lond)

Conference Name

Journal ISSN

0307-0565
1476-5497

Volume Title

39

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MC_UU_12015/1)
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MC_UU_12015/4)
British Heart Foundation (None)
Medical Research Council (MC_U106179471)
Medical Research Council (MC_U106179474)
Medical Research Council (MC_U106179473)