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Linear Increments with Non-monotone Missing Data and Measurement Error.

Published version
Peer-reviewed

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Authors

Seaman, Shaun R 
Farewell, Daniel 
White, Ian R 

Abstract

Linear increments (LI) are used to analyse repeated outcome data with missing values. Previously, two LI methods have been proposed, one allowing non-monotone missingness but not independent measurement error and one allowing independent measurement error but only monotone missingness. In both, it was suggested that the expected increment could depend on current outcome. We show that LI can allow non-monotone missingness and either independent measurement error of unknown variance or dependence of expected increment on current outcome but not both. A popular alternative to LI is a multivariate normal model ignoring the missingness pattern. This gives consistent estimation when data are normally distributed and missing at random (MAR). We clarify the relation between MAR and the assumptions of LI and show that for continuous outcomes multivariate normal estimators are also consistent under (non-MAR and non-normal) assumptions not much stronger than those of LI. Moreover, when missingness is non-monotone, they are typically more efficient.

Description

Keywords

ignorability, imputation, missing not at random, mortal cohort inference, non‐ignorable missing data, partly conditional inference

Journal Title

Scand Stat Theory Appl

Conference Name

Journal ISSN

0303-6898
1467-9469

Volume Title

43

Publisher

Wiley
Sponsorship
MRC (unknown)