Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
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Authors
Hveem, Kristian
Siersema, Peter D
Fedirko, Veronika
Kampman, Ellen
Halfweeg, Anouk
van Kranen, Henk J
van den Ouweland, Jody MW
Langhammer, Arnulf
Ness-Jensen, Eivind
Olsen, Anja
Cadeau, Claire
Boutron-Ruault, Marie-Christine
Katzke, Verena A
Boeing, Heiner
Trichopoulou, Antonia
Kotanidou, Anastasia
Kritikou, Maria
Panico, Salvatore
Peeters, Petra
Brustad, Magritt
Olsen, Karina Standahl
Lasheras, Cristina
Dorronsoro, Miren
Chirlaque, Maria-Dolores
Barricarte, Aurelio
Manjer, Jonas
Almquist, Martin
Renström, Frida
Norat, Teresa
Bueno-de-Mesquita, HB As
Publication Date
2018-03Journal Title
International journal of cancer
ISSN
0020-7136
Publisher
Wiley-Blackwell
Volume
142
Issue
6
Pages
1189-1201
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
van Duijnhoven, F. J., Jenab, M., Hveem, K., Siersema, P. D., Fedirko, V., Duell, E. J., Kampman, E., et al. (2018). Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.. International journal of cancer, 142 (6), 1189-1201. https://doi.org/10.1002/ijc.31146
Abstract
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2and 25(OH)D3combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Keywords
Humans, Pancreatic Neoplasms, Calcifediol, 25-Hydroxyvitamin D 2, Incidence, Risk Assessment, Case-Control Studies, Follow-Up Studies, Prospective Studies, Seasons, Aged, Middle Aged, Europe, Female, Male
Sponsorship
Department of Health (via National Institute for Health Research (NIHR)) (unknown)
National Institute for Health Research (NIHR) (NF-SI-0512-10114)
MEDICAL RESEARCH COUNCIL (MR/N003284/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Public Health Executive Agency (2006315)
Cancer Research UK (A2883)
MRC (G0401527)
MRC (G0500300)
Cancer Research UK (A7744)
Cancer Research UK (14136)
Cancer Research UK (A8257)
MRC (G1000143)
MRC (G0800603)
MRC (MC_UU_12015/1)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Medical Research Council (unknown)
Identifiers
External DOI: https://doi.org/10.1002/ijc.31146
This record's URL: https://www.repository.cam.ac.uk/handle/1810/277164
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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