Pros and cons of different therapeutic antibody formats for recombinant antivenom development.
Authors
Laustsen, Andreas H
María Gutiérrez, José
Knudsen, Cecilie
Bermúdez-Méndez, Erick
Cerni, Felipe A
Jürgensen, Jonas A
Ledsgaard, Line
Martos-Esteban, Andrea
Øhlenschlæger, Mia
Pus, Urska
Andersen, Mikael R
Lomonte, Bruno
Engmark, Mikael
Pucca, Manuela B
Publication Date
2018-05Journal Title
Toxicon
ISSN
0041-0101
Publisher
Elsevier BV
Volume
146
Pages
151-175
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Laustsen, A. H., María Gutiérrez, J., Knudsen, C., Johansen, K., Bermúdez-Méndez, E., Cerni, F. A., Jürgensen, J. A., et al. (2018). Pros and cons of different therapeutic antibody formats for recombinant antivenom development.. Toxicon, 146 151-175. https://doi.org/10.1016/j.toxicon.2018.03.004
Abstract
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to neutralize animal toxins. These different molecular formats each have their own therapeutic characteristics. In this review, we provide an overview of the advances made in the development of toxin-targeting antibodies, and discuss the benefits and drawbacks of different antibody formats in relation to their ability to neutralize toxins, pharmacokinetic features, propensity to cause adverse reactions, formulation, and expression for research and development (R&D) purposes and large-scale manufacturing. A research trend seems to be emerging towards the use of human antibody formats as well as camelid heavy-domain antibody fragments due to their compatibility with the human immune system, beneficial therapeutic properties, and the ability to manufacture these molecules cost-effectively.
Keywords
Venoms, Animals, Humans, Recombinant Proteins, Antivenins, Antibodies, Camelus
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1016/j.toxicon.2018.03.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/277227
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