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dc.contributor.authorPaling, David
dc.contributor.authorThade Petersen, Esben
dc.contributor.authorTozer, Daniel J
dc.contributor.authorAltmann, Daniel R
dc.contributor.authorWheeler-Kingshott, Claudia AM
dc.contributor.authorKapoor, Raju
dc.contributor.authorMiller, David H
dc.contributor.authorGolay, Xavier
dc.date.accessioned2018-06-22T12:49:06Z
dc.date.available2018-06-22T12:49:06Z
dc.date.issued2014-01
dc.identifier.issn0271-678X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/277405
dc.description.abstractAlterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In this study, a multiple delay time arterial spin labeling magnetic resonance imaging sequence at 3T was used to quantify the arterial hemodynamic parameter bolus arrival time (BAT) and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) and deep gray matter in 33 controls and 35 patients with relapsing-remitting MS. Bolus arrival time was prolonged in MS in NAWM (1.0±0.2 versus 0.9±0.2 seconds, P=0.031) and deep gray matter (0.90±0.18 versus 0.80±0.14 seconds, P=0.001) and CBF was increased in NAWM (14±4 versus 10±2 mL/100 g/min, P=0.001). Prolonged BAT in NAWM (P=0.042) and deep gray matter (P=0.01) were associated with higher expanded disability status score. This study demonstrates alteration in cerebral arterial hemodynamics in MS. One possible cause may be widespread inflammation. Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSAGE Publications
dc.subjectCerebral Arteries
dc.subjectHumans
dc.subjectMultiple Sclerosis
dc.subjectSpin Labels
dc.subjectMagnetic Resonance Imaging
dc.subjectBlood Flow Velocity
dc.subjectDisability Evaluation
dc.subjectLinear Models
dc.subjectCase-Control Studies
dc.subjectCerebrovascular Circulation
dc.subjectTime Factors
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectDisabled Persons
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.titleCerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability.
dc.typeArticle
prism.endingPage42
prism.issueIdentifier1
prism.publicationDate2014
prism.publicationNameJ Cereb Blood Flow Metab
prism.startingPage34
prism.volume34
dc.identifier.doi10.17863/CAM.24708
dcterms.dateAccepted2013-08-14
rioxxterms.versionofrecord10.1038/jcbfm.2013.161
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2014-01
dc.contributor.orcidTozer, Daniel [0000-0002-0404-3214]
dc.identifier.eissn1559-7016
rioxxterms.typeJournal Article/Review
cam.issuedOnline2013-09-18


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