Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables
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Peer-reviewed
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Abstract
In a group sequential clinical trial, accumulated data are analysed at numerous time-points in order to allow early decisions about a hypothesis of interest. These designs have historically been recommended for their ethical, administrative and economic bene fits. In this work, we discuss a collection of new Stata commands for computing the stopping boundaries and required group size of various classical group sequential designs, assuming a normally distributed outcome variable. Following this, we demonstrate how the performance of several designs can be compared graphically.
Description
Keywords
clinical trial design, doubletriangular, group sequential, haybittlepeto, innerwedge, powerfamily, st0529, triangular, wangtsiatis
Journal Title
Stata Journal
Conference Name
Journal ISSN
1536-867X
1536-8734
1536-8734
Volume Title
18
Publisher
DPC Nederland
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Sponsorship
Wellcome Trust (099770/Z/12/Z)
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