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dc.contributor.authorOuyang, J
dc.contributor.authorHardy, R
dc.contributor.authorBrown, M
dc.contributor.authorHelliwell, T
dc.contributor.authorGurnell, M
dc.contributor.authorCuthbertson, DJ
dc.date.accessioned2018-06-27T14:36:45Z
dc.date.available2018-06-27T14:36:45Z
dc.date.issued2017-07
dc.identifier.issn0950-9240
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/277578
dc.description.abstractPrimary hyperaldosteronism, characterised by hypertension and hypokalaemia, is a syndrome caused by aldosterone excess most commonly from either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Subtype classification can be challenging with cross-sectional imaging and even with interventional radiological techniques such as adrenal venous sampling. Imaging with 11C-metomidate positron emission tomography-computed tomography (PET-CT) is an emerging tool that facilitates functional characterisation and potentially successful surgical intervention of aldosterone-producing adenomas. This technique has highlighted that, although unilateral adenomas and bilateral hyperplasia represent opposite ends of the disease spectrum, a relatively common intermediate phenotype exists of unilateral/bilateral multinodular disease.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectHumans
dc.subjectAdenoma
dc.subjectAdrenal Gland Neoplasms
dc.subjectEtomidate
dc.subjectAldosterone
dc.subjectPositron Emission Tomography Computed Tomography
dc.title11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling.
dc.typeArticle
prism.endingPage484
prism.issueIdentifier7
prism.publicationDate2017
prism.publicationNameJ Hum Hypertens
prism.startingPage483
prism.volume31
dc.identifier.doi10.17863/CAM.24896
dcterms.dateAccepted2017-01-17
rioxxterms.versionofrecord10.1038/jhh.2017.9
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-07
dc.contributor.orcidGurnell, Mark [0000-0001-5745-6832]
dc.identifier.eissn1476-5527
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/M009041/1)
pubs.funder-project-idMedical Research Council (MR/M024873/1)
cam.issuedOnline2017-03-09


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