Repository logo
 

Reorganisation of brain networks in frontotemporal dementia and progressive supranuclear palsy.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Hughes, Laura E 
Ghosh, Boyd CP 
Rowe, James B 

Abstract

The disruption of large-scale brain networks is increasingly recognised as a consequence of neurodegenerative dementias. We assessed adults with behavioural variant frontotemporal dementia and progressive supranuclear palsy using magnetoencephalography during an auditory oddball paradigm. Network connectivity among bilateral temporal, frontal and parietal sources was examined using dynamic causal modelling. We found evidence for a systematic change in effective connectivity in both diseases. Compared with healthy subjects, who had focal modulation of intrahemispheric frontal-temporal connections, the patient groups showed abnormally extensive and inefficient networks. The changes in connectivity were accompanied by impaired responses of the auditory cortex to unexpected deviant tones (MMNm), despite normal responses to standard stimuli. Together, these results suggest that neurodegeneration in two distinct clinical syndromes with overlapping profiles of prefrontal atrophy, causes a similar pattern of reorganisation of large-scale networks. We discuss this network reorganisation in the context of other focal brain disorders and the specific vulnerability of functional brain networks to neurodegenerative disease.

Description

Keywords

Connectivity, Dementia, Dynamic causal modelling, MMNm, Magnetoencephalography

Journal Title

Neuroimage Clin

Conference Name

Journal ISSN

2213-1582
2213-1582

Volume Title

2

Publisher

Elsevier BV
Sponsorship
Medical Research Council (G0700503)
Medical Research Council (G0001354)
Medical Research Council (MC_U105597119)
Wellcome Trust (088324/Z/09/Z)
Medical Research Council (G1000183)