Sequential detection of multiple phase transitions in model biological membranes using a red-emitting conjugated polyelectrolyte.
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Repository DOI
Type
Article
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Authors
Houston, Judith E
Kraft, Mario
Scherf, Ullrich
Evans, Rachel Claire https://orcid.org/0000-0003-2956-4857
Abstract
The anionic conjugated polyelectrolyte, poly[3-(6-sulfothioatehexyl)thiophene] (P3Anionic), functions as a highly sensitive probe of membrane order, uniquely capable of sequentially detecting the three key phase transitions occurring within model phospholipid bilayers. The observed sensitivity is the result of charge-mediated, selective localisation of P3Anionic within the head-groups of the phospholipid bilayer.
Description
Keywords
Cell Membrane, Color, Lipid Bilayers, Models, Molecular, Molecular Conformation, Phase Transition, Polyelectrolytes, Polymers, Spectrometry, Fluorescence, Spectrophotometry, Ultraviolet, Sulfonic Acids, Thiophenes
Journal Title
Phys Chem Chem Phys
Conference Name
Journal ISSN
1463-9076
1463-9084
1463-9084
Volume Title
18
Publisher
Royal Society of Chemistry (RSC)