Functional immune characterization of HIV-associated non-small-cell lung cancer.
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Peer-reviewed
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Abstract
Dear Editor, In the combined anti-retroviral therapy (cART) era, non-small cell lung cancer (NSCLC) is a highly incident cause of morbidity and mortality in people living with HIV (PLHIV)[1]. The immune-pathogenesis of NSCLC and HIV infection both rely on programmed-death 1 (PD-1) receptor-ligand interaction as a mechanism to induce T-cell exhaustion. To date, PLHIV have been excluded from clinical trials of immune-checkpoint inhibitors (ICPI), on the presumption that anti-tumour immunity might be compromised by HIV infection. To verify this, we evaluated the clinico-pathologic significance of PD-ligands expression in a consecutive series of 221 archival NSCLC samples, 24 of which were HIV-associated (Table S1).
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Keywords
B7-H1 Antigen, Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung, HIV, HIV Infections, Humans, Lung Neoplasms, Lymphocytes, Tumor-Infiltrating, Prognosis
Journal Title
Ann Oncol
Conference Name
Journal ISSN
0923-7534
1569-8041
1569-8041
Volume Title
29
Publisher
Elsevier BV