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dc.contributor.authorPinato, DJen
dc.contributor.authorKythreotou, Aen
dc.contributor.authorMauri, FAen
dc.contributor.authorSuardi, Een
dc.contributor.authorAllara, Eliasen
dc.contributor.authorShiner, RJen
dc.contributor.authorAkarca, AUen
dc.contributor.authorTrivedi, Pen
dc.contributor.authorGupta, Nen
dc.contributor.authorDalla Pria, Aen
dc.contributor.authorMarafioti, Ten
dc.contributor.authorOliveri, Pen
dc.contributor.authorNewsom-Davis, Ten
dc.contributor.authorBower, Men
dc.date.accessioned2018-07-06T14:41:43Z
dc.date.available2018-07-06T14:41:43Z
dc.date.issued2018-06en
dc.identifier.issn0923-7534
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/277893
dc.description.abstractDear Editor, In the combined anti-retroviral therapy (cART) era, non-small cell lung cancer (NSCLC) is a highly incident cause of morbidity and mortality in people living with HIV (PLHIV)[1]. The immune-pathogenesis of NSCLC and HIV infection both rely on programmed-death 1 (PD-1) receptor-ligand interaction as a mechanism to induce T-cell exhaustion. To date, PLHIV have been excluded from clinical trials of immune-checkpoint inhibitors (ICPI), on the presumption that anti-tumour immunity might be compromised by HIV infection. To verify this, we evaluated the clinico-pathologic significance of PD-ligands expression in a consecutive series of 221 archival NSCLC samples, 24 of which were HIV-associated (Table S1).
dc.format.mediumPrinten
dc.languageengen
dc.publisherOUP
dc.subjectLymphocytes, Tumor-Infiltratingen
dc.subjectHumansen
dc.subjectHIVen
dc.subjectHIV Infectionsen
dc.subjectCarcinoma, Non-Small-Cell Lungen
dc.subjectLung Neoplasmsen
dc.subjectPrognosisen
dc.subjectBiomarkers, Tumoren
dc.subjectB7-H1 Antigenen
dc.titleFunctional immune characterization of HIV-associated non-small-cell lung cancer.en
dc.typeArticle
prism.endingPage1488
prism.issueIdentifier6en
prism.publicationDate2018en
prism.publicationNameAnnals of oncology : official journal of the European Society for Medical Oncologyen
prism.startingPage1486
prism.volume29en
dc.identifier.doi10.17863/CAM.25229
dcterms.dateAccepted2018-04-04en
rioxxterms.versionofrecord10.1093/annonc/mdy125en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-06en
dc.contributor.orcidAllara, Elias [0000-0002-1634-8330]
dc.contributor.orcidOliveri, P [0000-0002-3477-8529]
dc.contributor.orcidBower, M [0000-0002-4077-6351]
dc.identifier.eissn1569-8041
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2019-04-20


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