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dc.contributor.authorPrevost, Teresa C
dc.contributor.authorPresanis, Anne M
dc.contributor.authorTaylor, Avril
dc.contributor.authorGoldberg, David J
dc.contributor.authorHutchinson, Sharon J
dc.contributor.authorDe Angelis, Daniela
dc.date.accessioned2018-07-11T14:20:17Z
dc.date.available2018-07-11T14:20:17Z
dc.date.issued2015-08
dc.identifier.issn0965-2140
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278036
dc.description.abstractAIMS: To estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population remaining undiagnosed. METHODS: Information from routine surveillance (n=22616) and survey data (n=2511) was combined using a multiparameter evidence synthesis approach to estimate the size of the PWID population, HCV antibody prevalence and the proportion of HCV antibody prevalent cases who have been diagnosed, in subgroups defined by recency of injecting (in the last year or not), age (15-34 and 35-64 years), gender and region of residence (Greater Glasgow and Clyde and the rest of Scotland). RESULTS: HCV antibody-prevalence among PWID in Scotland during 2009 was estimated to be 57% [95% CI=52-61%], corresponding to 46657 [95% credible interval (CI)=33812-66803] prevalent cases. Of these, 27434 (95% CI=14636-47564) were undiagnosed, representing 59% [95% CI=43-71%] of prevalent cases. Among the undiagnosed, 83% (95% CI=75-89%) were PWID who had not injected in the last year and 71% (95% CI=58-85%) were aged 35-64 years. CONCLUSIONS: The number of undiagnosed hepatitis C virus-infected cases in Scotland appears to be particularly high among those who have injected drugs more than 1 year ago and are more than 35 years old.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherBlackwell Publishing Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectHepatitis C, Chronic
dc.subjectSubstance Abuse, Intravenous
dc.subjectHepatitis C Antibodies
dc.subjectEpidemiologic Methods
dc.subjectAge Distribution
dc.subjectSex Distribution
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectScotland
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.titleEstimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed: an evidence synthesis approach for Scotland.
dc.typeArticle
prism.endingPage1300
prism.issueIdentifier8
prism.publicationDate2015
prism.publicationNameAddiction
prism.startingPage1287
prism.volume110
dc.identifier.doi10.17863/CAM.25370
dcterms.dateAccepted2015-04-09
rioxxterms.versionofrecord10.1111/add.12948
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-08
dc.contributor.orcidPresanis, Anne [0000-0003-3078-4427]
dc.contributor.orcidDe Angelis, Daniela [0000-0001-6619-6112]
dc.identifier.eissn1360-0443
rioxxterms.typeJournal Article/Review
cam.issuedOnline2015-06-08


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International