Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Yiangou, Loukia
Ross, Alexander DB
Goh, Kim Jee
Vallier, Ludovic https://orcid.org/0000-0002-3848-2602
Abstract
The liver, lung, pancreas, and digestive tract all originate from the endoderm germ layer, and these vital organs are subject to many life-threatening diseases affecting millions of patients. However, primary cells from endodermal organs are often difficult to grow in vitro. Human pluripotent stem cells thus hold great promise for generating endoderm cells and their derivatives as tools for the development of new therapeutics against a variety of global healthcare challenges. Here we describe recent advances in methods for generating endodermal cell types from human pluripotent stem cells and their use for disease modeling and cell-based therapy.
Description
Keywords
disease modeling, endoderm, gut, human pluripotent stem cells, liver, lungs, pancreas, Endoderm, Humans, Models, Biological, Pluripotent Stem Cells
Journal Title
Cell Stem Cell
Conference Name
Journal ISSN
1934-5909
1875-9777
1875-9777
Volume Title
22
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Medical Research Council (MC_PC_12009)
European Research Council (741707)
National Centre for the Replacement Refinement and Reduction of Animals in Research (NC/N001540/1)
European Research Council (741707)
National Centre for the Replacement Refinement and Reduction of Animals in Research (NC/N001540/1)