Immune Activation in Sepsis.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Conway-Morris, Andrew https://orcid.org/0000-0002-3211-3216
Wilson, Julie
Shankar-Hari, Manu https://orcid.org/0000-0002-5338-2538
Abstract
Sepsis is caused by a dysregulated host response to infection. Immune responses determine the characteristics of sepsis. The body's protection against infection involves danger signal surveillance and recognition from nonself, effector functions in response to sensing danger signals, homeostatic regulation, and generation of immunologic memory. During sepsis, the immune system is activated by pathogen-associated and host-derived molecular patterns. Detecting these molecular patterns generates multisystem responses. Impaired organ function remote to the site of infection is the unifying feature. The processes by which an appropriate response to a microbial invader change from adaptive to maladaptive and dysregulated remain unclear.
Description
Keywords
Immunosuppression, Inflammation, Sepsis, Host-Pathogen Interactions, Humans, Immunity, Innate, Immunosuppression Therapy, Inflammation, Sepsis
Journal Title
Crit Care Clin
Conference Name
Journal ISSN
0749-0704
1557-8232
1557-8232
Volume Title
34
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (205214/Z/16/Z)