Critical thresholds for intracranial pressure vary over time in non-craniectomised traumatic brain injury patients.
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Nourallah, B., Zeiler, F., Calviello, L., Smielewski, P., Czosnyka, M., & Menon, D. (2018). Critical thresholds for intracranial pressure vary over time in non-craniectomised traumatic brain injury patients.. Acta neurochirurgica, 160 (7), 1315-1324. https://doi.org/10.1007/s00701-018-3555-3
Background: Intracranial pressure (ICP)- and cerebral perfusion pressure (CPP)- guided therapy is central to neurocritical care for traumatic brain injury (TBI) patients. We sought to identify time-dependent critical thresholds for mortality and unfavourable outcome for ICP and CPP in non-craniectomized TBI patients. Methods: This is a retrospective cohort study of 355 patients with moderate-to-severe TBI who received ICP monitoring and were managed without decompressive craniectomy in a tertiary hospital neurocritical care unit. Patients were grouped in 2x2 tables according to survival/death or favourable/unfavourable outcomes at 6 months, and serial thresholds of mean ICP and CPP, using increments of 0.1 and 0.5 mmHg respectively. Sequential chi-square analysis was performed and the thresholds yielding the highest chi-square test statistic were taken as having the best discriminative value for outcome. This process was repeated over monitoring periods of 1, 3, 5 and 7 days, and for each day of recording to establish time-dependent thresholds. The same analysis was performed for age and sex subgroups. Results: Global ICP thresholds were 21.3 mmHg and 20.5 mmHg for mortality and unfavourable outcome respectively (p<0.001). After the first day of ICP monitoring, ICP thresholds fell to between 15 – 20 mmHg and remained significant (p<0.05). Significant time-dependent CPP thresholds for mortality or unfavourable outcome were often not identified and no identifiable trends were produced. Conclusion: Critical ICP thresholds in non-craniectomized TBI patients vary with time and fall below established ICP targets after the first day of monitoring.
Humans, Retrospective Studies, Cerebrovascular Circulation, Intracranial Pressure, Adolescent, Adult, Middle Aged, Female, Male, Decompressive Craniectomy, Brain Injuries, Traumatic
EC FP7 CP (602150)
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External DOI: https://doi.org/10.1007/s00701-018-3555-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278342
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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