Imaging the healthy human brain with hyperpolarized 13C MRI
Authors
Hilborne, SF
Mason, JP
Coles, AJ
Publication Date
2018-06-18Conference Name
International Society of Magnetic Resonance in Medicine
Publisher
Wiley
Type
Conference Object
This Version
VoR
Metadata
Show full item recordCitation
Grist, J., McLean, M., Riemer, F., Zaccagna, F., Hilborne, S., Mason, J., Matys, T. M., et al. (2018). Imaging the healthy human brain with hyperpolarized 13C MRI. International Society of Magnetic Resonance in Medicine. https://www.ismrm.org/18m/
Abstract
Hyperpolarized 13C MR Spectroscopic Imaging (MRSI) can be used to probe human metabolism in vivo in real time. To date, this has been applied to studies of [1-13C] pyruvate metabolism in oncology and in the healthy human heart (1-3). Here we describe initial results from the first study to image [1-13C] pyruvate metabolism in the healthy human brain. The results show the feasibility of imaging the exchange of hyperpolarized 13C label between pyruvate and the endogenous lactate pool in the healthy brain as well as spectroscopic measurements of 13C-bicarbonate production.
Sponsorship
MRC (1508766)
Identifiers
External link: https://www.ismrm.org/18m/
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278402
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