Autophagy as a promoter of longevity: insights from model organisms.
Walker, David W
Nature reviews. Molecular cell biology
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Hansen, M., Rubinsztein, D., & Walker, D. W. (2018). Autophagy as a promoter of longevity: insights from model organisms.. Nature reviews. Molecular cell biology, 19 (9), 579-593. https://doi.org/10.1038/s41580-018-0033-y
Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and protect the cell against stressful conditions. Accordingly, it has been shown to play critical roles not only during development and disease, but accumulating evidence over the past decade also supports a direct role for autophagy in the ageing process. In particular, elegant studies using yeast, worms, flies, and mice have demonstrated a broad requirement for autophagy-related genes in the long lifespan observed in a number of conserved longevity paradigms. Moreover, several new and interesting concepts relevant to autophagy and its role in modulating longevity have been highlighted: (i) tissue-specific overexpression of single autophagy genes is sufficient to extend lifespan, (ii) selective types of autophagy may be critical for longevity, and (iii) autophagy can act in cell non-autonomous ways to influence organismal health and ageing. Understanding these mechanisms will be critical for modulating autophagy in approaches aimed at improving human healthspan.
Wellcome Trust (095317/Z/11/Z)
Wellcome Trust (100140/Z/12/Z)
External DOI: https://doi.org/10.1038/s41580-018-0033-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278442